Functions of transforming growth factor-β isoforms in the nervous system: cues based on localization and experimental in vitro and in vivo evidence
This review briefly describes the cellular distribution and documented roles of the transforming growth factor (TGF)-β isoforms TGF-β2 and -β3 in the central and peripheral nervous system. TGF-β2 and -β3 are coexpressed in developing radial glial and mature astroglial and Schwann cells, as well as i...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
December 2000
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| In: |
EJB
Year: 2000, Volume: 267, Issue: 24, Pages: 6972-6975 |
| ISSN: | 1432-1033 |
| DOI: | 10.1046/j.1432-1327.2000.01824.x |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1046/j.1432-1327.2000.01824.x Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/10.1046/j.1432-1327.2000.01824.x/abstract 
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| Author Notes: | Klaus Unsicker and Jens Strelau |
| Summary: | This review briefly describes the cellular distribution and documented roles of the transforming growth factor (TGF)-β isoforms TGF-β2 and -β3 in the central and peripheral nervous system. TGF-β2 and -β3 are coexpressed in developing radial glial and mature astroglial and Schwann cells, as well as in subpopulations of differentiated neurons, most prominently in cortical, hippocampal, and brainstem/spinal cord motor neurons. In vitro studies have suggested a number of potential, physiologically relevant functions for TGF-βs including regulation of astroglial cell proliferation, expression of adhesion molecules, survival promoting roles for neurons in combination with established neurotrophic factors, and differentiative actions on neurons. |
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| Item Description: | Gesehen am 02.06.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1432-1033 |
| DOI: | 10.1046/j.1432-1327.2000.01824.x |