Observations on the structure of myelin lacking the major proteolipid protein: scientific correspondence
Proteolipid protein (PLP) and its smaller DM20 isoform account for approximately 50% of protein in central nervous system myelin, suggesting an important role in myelination. PLP/DM20-deficient mice generated by gene targeting techniques assemble large amounts of myelin, although it displays a varie...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2002
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| In: |
Neuropathology & applied neurobiology
Year: 2002, Jahrgang: 28, Heft: 1, Pages: 75-78 |
| ISSN: | 1365-2990 |
| DOI: | undefined |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/undefined Verlag, Volltext: http://www.redi-bw.de/db/ebsco.php/search.ebscohost.com/login.aspx%3fdirect%3dtrue%26db%3da9h%26AN%3d12673337%26site%3dehost-live 
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| Verfasserangaben: | D. Yool, M. Klugmann, J.A. Barrie, M.C. McCulloch, K.-A. Nave, I.R. Griffiths |
| Zusammenfassung: | Proteolipid protein (PLP) and its smaller DM20 isoform account for approximately 50% of protein in central nervous system myelin, suggesting an important role in myelination. PLP/DM20-deficient mice generated by gene targeting techniques assemble large amounts of myelin, although it displays a variety of defects at the intraperiod line (IPL) when prepared for conventional electron microscopy. The appearance of the PLP/DM20-deficient myelin prepared by freeze substitution showed a similar range of IPL defects to that prepared by conventional fixation and also included regions containing a normal IPL. |
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| Beschreibung: | Gesehen am 08.06.2017 |
| Beschreibung: | Online Resource |
| ISSN: | 1365-2990 |
| DOI: | undefined |