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Observations on the structure of myelin lacking the major proteolipid protein: scientific correspondence

Proteolipid protein (PLP) and its smaller DM20 isoform account for approximately 50% of protein in central nervous system myelin, suggesting an important role in myelination. PLP/DM20-deficient mice generated by gene targeting techniques assemble large amounts of myelin, although it displays a varie...

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Bibliographische Detailangaben
Hauptverfasser: Yool, Donald A. (VerfasserIn) , Klugmann, Matthias (VerfasserIn) , Nave, Klaus-Armin (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2002
In: Neuropathology & applied neurobiology
Year: 2002, Jahrgang: 28, Heft: 1, Pages: 75-78
ISSN:1365-2990
DOI:undefined
Online-Zugang:Verlag, Volltext: http://dx.doi.org/undefined
Verlag, Volltext: http://www.redi-bw.de/db/ebsco.php/search.ebscohost.com/login.aspx%3fdirect%3dtrue%26db%3da9h%26AN%3d12673337%26site%3dehost-live
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Verfasserangaben:D. Yool, M. Klugmann, J.A. Barrie, M.C. McCulloch, K.-A. Nave, I.R. Griffiths

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520 |a Proteolipid protein (PLP) and its smaller DM20 isoform account for approximately 50% of protein in central nervous system myelin, suggesting an important role in myelination. PLP/DM20-deficient mice generated by gene targeting techniques assemble large amounts of myelin, although it displays a variety of defects at the intraperiod line (IPL) when prepared for conventional electron microscopy. The appearance of the PLP/DM20-deficient myelin prepared by freeze substitution showed a similar range of IPL defects to that prepared by conventional fixation and also included regions containing a normal IPL. 
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