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Glyoxalase 1 expression is associated with an unfavorable prognosis of oropharyngeal squamous cell carcinoma

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Glyoxalase 1 is a key enzyme in the detoxification of reactive metabolites such as methylglyoxal and induced Glyoxalase 1 expression has been demonstrated for several human malignancies. However, the regulation and clinical relevance of Glyoxalase 1 in the context of head and neck squamous cell carc...

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Bibliographic Details
Main Authors: Kreycy, Nele (Author) , Fleming, Thomas (Author) , Flechtenmacher, Christa (Author) , Grabe, Niels (Author) , Plinkert, Peter K. (Author) , Heß, Jochen (Author) , Plath, Karim (Author)
Format: Article (Journal)
Language:English
Published: 26 May 2017
In: BMC cancer
Year: 2017, Volume: 17
ISSN:1471-2407
DOI:10.1186/s12885-017-3367-5
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s12885-017-3367-5
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Author Notes:Nele Kreycy, Christiane Gotzian, Thomas Fleming, Christa Flechtenmacher, Niels Grabe, Peter Plinkert, Jochen Hess and Karim Zaoui
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Summary:Glyoxalase 1 is a key enzyme in the detoxification of reactive metabolites such as methylglyoxal and induced Glyoxalase 1 expression has been demonstrated for several human malignancies. However, the regulation and clinical relevance of Glyoxalase 1 in the context of head and neck squamous cell carcinoma has not been addressed so far.
Item Description:Gesehen am 09.06.2017
Physical Description:Online Resource
ISSN:1471-2407
DOI:10.1186/s12885-017-3367-5

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