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Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile

A lot of attention has been paid to Latino heterogeneity related to individual proportions of Native American, European and African ancestry. The importance of the type of Native American ancestry for health, however, has hardly been studied. Here we examined genetic data from 2,039 admixed Chileans...

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Bibliographische Detailangaben
Hauptverfasser: Lorenzo Bermejo, Justo (VerfasserIn) , Boekstegers, Felix (VerfasserIn) , González Silos, Rosa (VerfasserIn) , Barahona Ponce, Carol (VerfasserIn) , Fischer, Christine (VerfasserIn) , Peil, Barbara (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: May 25, 2017
In: PLoS Genetics
Year: 2017, Jahrgang: 13, Heft: 5
ISSN:1553-7404
DOI:10.1371/journal.pgen.1006756
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pgen.1006756
Verlag, kostenfrei, Volltext: http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1006756
Volltext
Verfasserangaben:Justo Lorenzo Bermejo, Felix Boekstegers, Rosa González Silos, Katherine Marcelain, Pablo Baez Benavides, Carol Barahona Ponce, Bettina Müller, Catterina Ferreccio, Jill Koshiol, Christine Fischer, Barbara Peil, Janet Sinsheimer, Macarena Fuentes Guajardo, Olga Barajas, Rolando Gonzalez-Jose, Gabriel Bedoya, Maria Cátira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Andres Ruiz Linares, Francisco Rothhammer
Beschreibung
Zusammenfassung:A lot of attention has been paid to Latino heterogeneity related to individual proportions of Native American, European and African ancestry. The importance of the type of Native American ancestry for health, however, has hardly been studied. Here we examined genetic data from 2,039 admixed Chileans to investigate possible associations between top causes of death and the two major types of Native American ancestry in Chile. Our findings demonstrate the necessity of suitable surrogates for ancestry estimation which mirror the actual composition of the study population, and the advantage of considering fine-scale Latino heterogeneity for unraveling of disease etiology and personalized healthcare.
Beschreibung:Gesehen am 19.06.2017
Beschreibung:Online Resource
ISSN:1553-7404
DOI:10.1371/journal.pgen.1006756

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