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Regulation of plant stem cell quiescence by a brassinosteroid signaling module

The quiescent center (QC) maintains the activity of the surrounding stem cells within the root stem cell niche, yet specific molecular players sustaining the low rate of QC cell division remain poorly understood. Here, we identified a R2R3-MYB transcription factor, BRAVO (BRASSINOSTEROIDS AT VASCULA...

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Main Authors: Vilarrasa-Blasi, Josep (Author) , González-García, Mary-Paz (Author) , Lohmann, Jan U. (Author)
Format: Article (Journal)
Language:English
Published: 20 April 2014
In: Developmental cell
Year: 2014, Volume: 30, Issue: 1, Pages: 36-47
ISSN:1878-1551
DOI:10.1016/j.devcel.2014.05.020
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.devcel.2014.05.020
Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S1534580714003402
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Author Notes:Josep Vilarrasa-Blasi, Mary-Paz González-García, David Frigola, Norma Fàbregas, Konstantinos G. Alexiou, Nuria López-Bigas, Susana Rivas, Alain Jauneau, Jan U. Lohmann, Philip N. Benfey, Marta Ibañes, Ana I. Caño-Delgado
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Summary:The quiescent center (QC) maintains the activity of the surrounding stem cells within the root stem cell niche, yet specific molecular players sustaining the low rate of QC cell division remain poorly understood. Here, we identified a R2R3-MYB transcription factor, BRAVO (BRASSINOSTEROIDS AT VASCULAR AND ORGANIZING CENTER), acting as a cell-specific repressor of QC divisions in the primary root of Arabidopsis. Ectopic BRAVO expression restricts overall root growth and ceases root regeneration upon damage of the stem cells, demonstrating the role of BRAVO in counteracting Brassinosteroid (BR)-mediated cell division in the QC cells. Interestingly, BR-regulated transcription factor BES1 (BRI1-EMS SUPRESSOR 1) directly represses and physically interacts with BRAVO in vivo, creating a switch that modulates QC divisions at the root stem cell niche. Together, our results define a mechanism for BR-mediated regulation of stem cell quiescence in plants.
Item Description:Gesehen am 19.06.2017
Physical Description:Online Resource
ISSN:1878-1551
DOI:10.1016/j.devcel.2014.05.020

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