Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres
Cellular contractility is regulated by the GTPase RhoA, but how local signals are translated to a cell-level response is not known. Here the authors show that targeted RhoA activation results in propagation of force along stress fibres and actin flow.
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 Jun 2017
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| In: |
Nature Communications
Year: 2017, Jahrgang: 8 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms15817 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/ncomms15817 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/ncomms15817 
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| Verfasserangaben: | Patrick W. Oakes, Elizabeth Wagner, Christoph A. Brand, Dimitri Probst, Marco Linke, Ulrich S. Schwarz, Michael Glotzer & Margaret L. Gardel |
| Zusammenfassung: | Cellular contractility is regulated by the GTPase RhoA, but how local signals are translated to a cell-level response is not known. Here the authors show that targeted RhoA activation results in propagation of force along stress fibres and actin flow. |
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| Beschreibung: | Gesehen am 28.06.2017 |
| Beschreibung: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/ncomms15817 |