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Optimized protocol for high resolution functional magnetic resonance imaging at 3T using single-shot echo planar imaging

To translate highly accelerated EPI-fMRI protocols as commonly used at ultra-high field strengths to clinical 3T settings. EPI protocols with increasing matrix sizes and parallel imaging (PI) factors were tested in two separate fMRI studies, a simple motor-task and a complex motivation-task experime...

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Hauptverfasser: Domsch, Sebastian (VerfasserIn) , Zapp, Jascha (VerfasserIn) , Schad, Lothar R. (VerfasserIn) , Nees, Frauke (VerfasserIn) , Hill, Holger (VerfasserIn) , Hermann, Derik (VerfasserIn) , Mann, Karl (VerfasserIn) , Vollstädt-Klein, Sabine (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 15 January 2015
In: Journal of neuroscience methods
Year: 2015, Jahrgang: 239, Pages: 170-182
ISSN:1872-678X
DOI:10.1016/j.jneumeth.2014.10.014
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1016/j.jneumeth.2014.10.014
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0165027014003811
Volltext
Verfasserangaben:Sebastian Domsch, Jascha Zapp, Lothar R. Schad, Frauke Nees, Holger Hill, Derik Hermann, Karl Mann, Sabine Vollstädt-Klein
Beschreibung
Zusammenfassung:To translate highly accelerated EPI-fMRI protocols as commonly used at ultra-high field strengths to clinical 3T settings. EPI protocols with increasing matrix sizes and parallel imaging (PI) factors were tested in two separate fMRI studies, a simple motor-task and a complex motivation-task experiment with focus on the sensorimotor cortex (SMC) and the nucleus accumbens (NAcc), respectively. By increasing the matrix size and the PI-factor simultaneously, BOLD-sensitivity in terms of maximal t-values and numbers of activated clusters was uncompromised in single individuals in both fMRI experiments. In the SMC, the multi-subject analysis revealed an increase of 66% of the maximal t-value whereby the number of activated clusters was increased by a factor of 3.3 when the matrix size (PI-factor) was increased from 96×96 (R=2) to 192×192 (R=4). In the NAcc, the number of activated clusters increased from 5 to 7 whereby the maximal t-value remained unaffected when the matrix size (PI-factor) was increased from 96×96 (R=2) to 160×160 (R=3). Using the proposed high-resolution EPI protocol, spatial blurring was clearly reduced. Further, BOLD sensitivity was clearly improved in multi-subject analyses and remained unaffected in single individuals compared to using the standard protocols. Conventionally used matrix sizes (PI-factors) might be non-optimal for some applications sacrificing BOLD spatial specificity. We recommend using the proposed high-resolution protocols applicable in detecting robust BOLD activation in fMRI.
Beschreibung:Gesehen am 06.07.2017
Beschreibung:Online Resource
ISSN:1872-678X
DOI:10.1016/j.jneumeth.2014.10.014

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