Optimized protocol for high resolution functional magnetic resonance imaging at 3T using single-shot echo planar imaging
To translate highly accelerated EPI-fMRI protocols as commonly used at ultra-high field strengths to clinical 3T settings. EPI protocols with increasing matrix sizes and parallel imaging (PI) factors were tested in two separate fMRI studies, a simple motor-task and a complex motivation-task experime...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 January 2015
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| In: |
Journal of neuroscience methods
Year: 2015, Volume: 239, Pages: 170-182 |
| ISSN: | 1872-678X |
| DOI: | 10.1016/j.jneumeth.2014.10.014 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.jneumeth.2014.10.014 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0165027014003811 
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| Author Notes: | Sebastian Domsch, Jascha Zapp, Lothar R. Schad, Frauke Nees, Holger Hill, Derik Hermann, Karl Mann, Sabine Vollstädt-Klein |
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| 520 | |a To translate highly accelerated EPI-fMRI protocols as commonly used at ultra-high field strengths to clinical 3T settings. EPI protocols with increasing matrix sizes and parallel imaging (PI) factors were tested in two separate fMRI studies, a simple motor-task and a complex motivation-task experiment with focus on the sensorimotor cortex (SMC) and the nucleus accumbens (NAcc), respectively. By increasing the matrix size and the PI-factor simultaneously, BOLD-sensitivity in terms of maximal t-values and numbers of activated clusters was uncompromised in single individuals in both fMRI experiments. In the SMC, the multi-subject analysis revealed an increase of 66% of the maximal t-value whereby the number of activated clusters was increased by a factor of 3.3 when the matrix size (PI-factor) was increased from 96×96 (R=2) to 192×192 (R=4). In the NAcc, the number of activated clusters increased from 5 to 7 whereby the maximal t-value remained unaffected when the matrix size (PI-factor) was increased from 96×96 (R=2) to 160×160 (R=3). Using the proposed high-resolution EPI protocol, spatial blurring was clearly reduced. Further, BOLD sensitivity was clearly improved in multi-subject analyses and remained unaffected in single individuals compared to using the standard protocols. Conventionally used matrix sizes (PI-factors) might be non-optimal for some applications sacrificing BOLD spatial specificity. We recommend using the proposed high-resolution protocols applicable in detecting robust BOLD activation in fMRI. | ||
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