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Serum sCD95L concentration in patients with spinal cord injury

ObjectiveTo determine serum concentrations of soluble CD95 ligand (sCD95L) in patients with traumatic spinal cord injury.MethodsPatients with traumatic spinal cord injury were recruited. Blood was collected on admission to hospital and at 4?h, 9?h, 12?h, 24?h, 3 days, 7 days, and 2, 4, 8 and 12 week...

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Main Authors: Biglari, Bahram (Author) , Büchler, Axel (Author) , Swing, Tyler (Author) , Child, Christopher (Author) , Bruckner, Thomas (Author) , Ferbert, Thomas (Author) , Korff, Sebastian (Author) , Rief, Harald (Author) , Gerner, Hans-Jürgen (Author) , Moghaddam-Alvandi, Arash (Author)
Format: Article (Journal)
Language:English
Published: 19 January 2015
In: The journal of international medical research
Year: 2015, Volume: 43, Issue: 2, Pages: 250-256
ISSN:1473-2300
DOI:10.1177/0300060514559794
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1177/0300060514559794
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Author Notes:Bahram Biglari, Axel Büchler, Tyler Swing, Christopher Child, Elisabeth Biehl, Tim Reitzel, Tom Bruckner, Thomas Ferbert, Sebastian Korff, Harald Rief, Hans-Jürgen Gerner and Arash Moghaddam
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Summary:ObjectiveTo determine serum concentrations of soluble CD95 ligand (sCD95L) in patients with traumatic spinal cord injury.MethodsPatients with traumatic spinal cord injury were recruited. Blood was collected on admission to hospital and at 4?h, 9?h, 12?h, 24?h, 3 days, 7 days, and 2, 4, 8 and 12 weeks postadmission. Serum concentrations of sCD95L were determined via immunoassay.ResultThe study included 23 patients. Mean sCD95L concentrations were significantly lower at 4?h, 9?h, 12?h and 24?h than at admission, and were significantly higher at 8 and 12 weeks, compared with admission.ConclusionThe serum sCD95L concentration fell significantly during the first 24?h after traumatic spinal cord injury. Concentrations then rose, becoming significantly higher than admission levels at 8 weeks. sCD95L may represent a possible therapeutic target for traumatic spinal cord injury.
Item Description:Gesehen am 14.07.2017
Physical Description:Online Resource
ISSN:1473-2300
DOI:10.1177/0300060514559794

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