Analytical model for macromolecular partitioning during yeast cell division
Asymmetric cell division, whereby a parent cell generates two sibling cells with unequal content and thereby distinct fates, is central to cell differentiation, organism development and ageing. Unequal partitioning of the macromolecular content of the parent cell which includes proteins, DNA, RNA, l...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 September 2014
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| In: |
BMC Biophysics
Year: 2014, Volume: 7, Pages: ? |
| ISSN: | 2046-1682 |
| DOI: | 10.1186/s13628-014-0010-6 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13628-014-0010-6
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| Author Notes: | Ali Kinkhabwala, Anton Khmelinskii and Michael Knop |
| Summary: | Asymmetric cell division, whereby a parent cell generates two sibling cells with unequal content and thereby distinct fates, is central to cell differentiation, organism development and ageing. Unequal partitioning of the macromolecular content of the parent cell which includes proteins, DNA, RNA, large proteinaceous assemblies and organelles can be achieved by both passive (e.g. diffusion, localized retention sites) and active (e.g. motor-driven transport) processes operating in the presence of external polarity cues, internal asymmetries, spontaneous symmetry breaking, or stochastic effects. However, the quantitative contribution of different processes to the partitioning of macromolecular content is difficult to evaluate. |
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| Item Description: | Gesehen am 09.08.2017 |
| Physical Description: | Online Resource |
| ISSN: | 2046-1682 |
| DOI: | 10.1186/s13628-014-0010-6 |