Revealing age-related changes of adult hippocampal neurogenesis
In the adult hippocampus, neural stem cells (NSCs) continuously produce new neurons that integrate into the neuronal network to modulate learning and memory. The amount and quality of newly generated neurons decline with age, which can be counteracted by increasing intrinsic Wnt activity in NSCs. Ho...
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| Main Authors: | , , , |
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| Format: | Article (Journal) Chapter/Article |
| Language: | English |
| Published: |
February 27, 2017
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| In: |
bioRxiv beta
Year: 2017, Pages: 1-27 |
| DOI: | 10.1101/112128 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1101/112128 Verlag, Volltext: http://www.biorxiv.org/content/early/2017/02/27/112128 
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| Author Notes: | Frederik Ziebell, Sascha Dehler, Ana Martin-Villalba, Anna Marciniak-Czochra |
| Summary: | In the adult hippocampus, neural stem cells (NSCs) continuously produce new neurons that integrate into the neuronal network to modulate learning and memory. The amount and quality of newly generated neurons decline with age, which can be counteracted by increasing intrinsic Wnt activity in NSCs. However, the precise cellular changes underlying this age-related decline or its rescue through Wnt remain unclear. The present study combines development of a mathematical model and experimental data to address features controlling stem cell dynamics. We show that available experimental data fit a model in which quiescent NSCs can either become activated to divide or undergo depletion events, consisting of astrocytic transformation and apoptosis. Additionally, we demonstrate that aged NSCs remain longer in quiescence and have a higher probability to become re-activated versus being depleted. Finally, our model explains that high NSC-Wnt activity leads to longer time in quiescence while augmenting the probability of activation.</p> |
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| Item Description: | Gesehen am 21.08.2017 |
| Physical Description: | Online Resource |
| DOI: | 10.1101/112128 |