Chronic mast cell leukemia: a novel leukemia-variant with distinct morphological and clinical features
Mast cell leukemia (MCL) is a rare form of systemic mastocytosis characterized by leukemic expansion of mostly immature mast cells, organ damage, drug-resistance, and a poor prognosis. Even when treated with chemotherapy, most patients have a life-expectancy of less than one year. However, there are...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 2015
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| In: |
Leukemia research
Year: 2015, Volume: 39, Issue: 1, Pages: 1-5 |
| ISSN: | 1873-5835 |
| DOI: | 10.1016/j.leukres.2014.09.010 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.leukres.2014.09.010 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0145212614002926 
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| Author Notes: | Peter Valent, Karl Sotlar, Wolfgang R. Sperr, Andreas Reiter, Michel Arock, Hans-Peter Horny |
| Summary: | Mast cell leukemia (MCL) is a rare form of systemic mastocytosis characterized by leukemic expansion of mostly immature mast cells, organ damage, drug-resistance, and a poor prognosis. Even when treated with chemotherapy, most patients have a life-expectancy of less than one year. However, there are rare patients with MCL in whom the condition is less aggressive and does not cause organ damage within a short time. In these patients, mast cells exhibit a more mature morphology when compared to acute MCL. A recently proposed classification suggests that these cases are referred to as chronic MCL. In the present article, we discuss clinical, histopathological and morphological aspects of acute and chronic MCL. |
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| Item Description: | Gesehen am 30.08.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1873-5835 |
| DOI: | 10.1016/j.leukres.2014.09.010 |