Chronic mast cell leukemia: a novel leukemia-variant with distinct morphological and clinical features
Mast cell leukemia (MCL) is a rare form of systemic mastocytosis characterized by leukemic expansion of mostly immature mast cells, organ damage, drug-resistance, and a poor prognosis. Even when treated with chemotherapy, most patients have a life-expectancy of less than one year. However, there are...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 2015
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| In: |
Leukemia research
Year: 2015, Jahrgang: 39, Heft: 1, Pages: 1-5 |
| ISSN: | 1873-5835 |
| DOI: | 10.1016/j.leukres.2014.09.010 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.leukres.2014.09.010 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0145212614002926 
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| Verfasserangaben: | Peter Valent, Karl Sotlar, Wolfgang R. Sperr, Andreas Reiter, Michel Arock, Hans-Peter Horny |
MARC
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| 520 | |a Mast cell leukemia (MCL) is a rare form of systemic mastocytosis characterized by leukemic expansion of mostly immature mast cells, organ damage, drug-resistance, and a poor prognosis. Even when treated with chemotherapy, most patients have a life-expectancy of less than one year. However, there are rare patients with MCL in whom the condition is less aggressive and does not cause organ damage within a short time. In these patients, mast cells exhibit a more mature morphology when compared to acute MCL. A recently proposed classification suggests that these cases are referred to as chronic MCL. In the present article, we discuss clinical, histopathological and morphological aspects of acute and chronic MCL. | ||
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