Synthesis of 3-chloro-6-((4-(di-tert-butyl[18F]fluorosilyl)-benzyl)oxy)-1,2,4,5-tetrazine ([18F]SiFA-OTz) for rapid tetrazine-based 18F-radiolabeling
An efficient method to prepare the 18F-labeled tetrazine-derivative [18F]-SiFA-OTz for bioorthogonal radiochemistry was developed. [18F]-SiFA-OTz can be synthesized with a radiochemical yield of 78 ± 5% within 25 min and can quantitatively react with a model strained dienophile, trans-cyclooctenol.
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 June 2015
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| In: |
Chemical communications
Year: 2015, Volume: 51, Issue: 62, Pages: 12415-12418 |
| ISSN: | 1364-548X |
| DOI: | 10.1039/C5CC03623B |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1039/C5CC03623B Verlag, Volltext: http://pubs.rsc.org/en/content/articlelanding/2015/cc/c5cc03623b 
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| Author Notes: | Jun Zhu, Stephen Li, Carmen Wängler, Björn Wängler, R. Bruce Lennox, Ralf Schirrmacher |
| Summary: | An efficient method to prepare the 18F-labeled tetrazine-derivative [18F]-SiFA-OTz for bioorthogonal radiochemistry was developed. [18F]-SiFA-OTz can be synthesized with a radiochemical yield of 78 ± 5% within 25 min and can quantitatively react with a model strained dienophile, trans-cyclooctenol. |
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| Item Description: | Gesehen am 31.08.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1364-548X |
| DOI: | 10.1039/C5CC03623B |