Targeting neutrophils to prevent malaria-associated acute lung injury/acute respiratory distress syndrome in mice
Author Summary A deeper understanding of the pathogenesis of malaria-associated ALI/ARDS may help in the development of new therapeutic approaches to improve the prognosis of severe cases of malaria. Using the Plasmodium berghei ANKA-infection mouse model of ALI/ARDS, which resembles the human disea...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
7 December 2016
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| In: |
PLoS pathogens
Year: 2016, Volume: 12, Issue: 12 |
| ISSN: | 1553-7374 |
| DOI: | 10.1371/journal.ppat.1006054 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1371/journal.ppat.1006054 Verlag, Volltext: http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006054 
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| Author Notes: | Michelle K. Sercundes, Luana S. Ortolan, Daniela Debone, Paulo V. Soeiro-Pereira, Eliane Gomes, Elizabeth H. Aitken, Antonio Condino Neto, Momtchilo Russo, Maria R. D' Império Lima, José M. Alvarez, Silvia Portugal, Claudio R.F. Marinho, Sabrina Epiphanio |
| Summary: | Author Summary A deeper understanding of the pathogenesis of malaria-associated ALI/ARDS may help in the development of new therapeutic approaches to improve the prognosis of severe cases of malaria. Using the Plasmodium berghei ANKA-infection mouse model of ALI/ARDS, which resembles the human disease in many aspects, this study reports the critical role of neutrophils in the pathogenesis of this syndrome. Mice developing ALI/ARDS showed abundant lung-infiltrating neutrophils in association with the increased production of neutrophil-attracting chemokines, myeloperoxidase and reactive oxygen species. The parasites Plasmodium falciparum and P. berghei ANKA both induced the formation of neutrophil extracellular traps ex vivo. By targeting neutrophils and neutrophil extracellular traps with specific drugs, we succeeded in preventing the development of malaria-associated ALI/ARDS and significantly increased mouse survival. |
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| Item Description: | Gesehen am 26.09.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1553-7374 |
| DOI: | 10.1371/journal.ppat.1006054 |