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Gene variations in GSTM3 are a risk factor for Alzheimer's disease

Oxidative stress is a relevant pathomechanism in Alzheimer's disease (AD) and gene variations in the glutathione S-transferase M3 gene (GSTM3), involved in the detoxification of oxygen radicals, might influence the risk of AD. We investigated the effect of three polymorphisms in GSTM3: rs133201...

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Bibliographic Details
Main Authors: Hong, Gun-Soo (Author) , Hentschel, Frank (Author)
Format: Article (Journal)
Language:English
Published: [May 2009]
In: Neurobiology of aging
Year: 2009, Volume: 30, Issue: 5, Pages: 691-696
ISSN:1558-1497
DOI:10.1016/j.neurobiolaging.2007.08.012
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.neurobiolaging.2007.08.012
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0197458007003466
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Author Notes:G.-S. Hong, R. Heun, F. Jessen, J. Popp, F. Hentschel, P. Kelemen, A. Schulz, W. Maier, H. Kölsch
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Summary:Oxidative stress is a relevant pathomechanism in Alzheimer's disease (AD) and gene variations in the glutathione S-transferase M3 gene (GSTM3), involved in the detoxification of oxygen radicals, might influence the risk of AD. We investigated the effect of three polymorphisms in GSTM3: rs1332018 (C/A); rs1799735 (del/AGG); rs7483 (G/A), on the risk of AD in 363 AD patients and 358 healthy controls. Single marker association analyses revealed that the AGG/AGG genotype of the GSTM3 rs1799735 (del/AGG) polymorphism was associated with an increased risk of AD (p=0.05), especially in the group of APOE4-allele non-carriers (p=0.004; OR=2.07). Examination of the haplotypes identified a two-marker haplotype (C/AGG) consisting of rs1332018 (C/A) and rs1799735 (del/AGG) to increase the risk of AD (p=0.029), this effect was also most prevalent in APOE4-allele non-carriers (p=0.009; OR=1.95). The population attributable risk of this haplotype in APOE4-allele non-carriers was 32.2%. Our results suggest that there is a group of AD patients in which variations in metabolism of oxidative stress play an important role.
Item Description:Gesehen am 05.10.2017
Physical Description:Online Resource
ISSN:1558-1497
DOI:10.1016/j.neurobiolaging.2007.08.012

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