Antitrypanosomal activities of proteasome inhibitors
Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential o...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2002
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| In: |
Antimicrobial agents and chemotherapy
Year: 2002, Volume: 46, Issue: 6, Pages: 2038-2040 |
| ISSN: | 1098-6596 |
| DOI: | 10.1128/AAC.46.6.2038-2040.2002 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1128/AAC.46.6.2038-2040.2002
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| Author Notes: | Joseph Nkemgu-Njinkeng, Vera Rosenkranz, Michael Wink and Dietmar Steverding |
| Summary: | Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of proteasome inhibitors for rational antitrypanosomal drug development. |
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| Item Description: | Gesehen am 05.10.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1098-6596 |
| DOI: | 10.1128/AAC.46.6.2038-2040.2002 |