Antitrypanosomal activities of proteasome inhibitors
Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential o...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2002
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| In: |
Antimicrobial agents and chemotherapy
Year: 2002, Jahrgang: 46, Heft: 6, Pages: 2038-2040 |
| ISSN: | 1098-6596 |
| DOI: | 10.1128/AAC.46.6.2038-2040.2002 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1128/AAC.46.6.2038-2040.2002
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| Verfasserangaben: | Joseph Nkemgu-Njinkeng, Vera Rosenkranz, Michael Wink and Dietmar Steverding |
| Zusammenfassung: | Seven peptidyl proteasome inhibitors were tested for in vitro activity against Trypanosoma brucei bloodstream forms. Two compounds showed activity in the low nanomolar range. In general, trypanosomes were more susceptible to the compounds than were human HL-60 cells. The data support the potential of proteasome inhibitors for rational antitrypanosomal drug development. |
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| Beschreibung: | Gesehen am 05.10.2017 |
| Beschreibung: | Online Resource |
| ISSN: | 1098-6596 |
| DOI: | 10.1128/AAC.46.6.2038-2040.2002 |