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No association of Vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults

Background: Several investigations assessed the association of vitamin D receptor (VDR) SNPs with cancer risk. Less is known about the implications of other vitamin D pathway SNPs on cancer risk. Methods: In a population-based cohort study of 9,949 German older adults, we used Cox regression to asse...

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Main Authors: Ordóñez Mena, José M. (Author) , Schöttker, Ben (Author) , Saum, Kai-Uwe (Author) , Burwinkel, Barbara (Author) , Brenner, Hermann (Author)
Format: Article (Journal)
Language:English
Published: September 2017
In: Cancer epidemiology, biomarkers & prevention
Year: 2017, Volume: 26, Issue: 9, Pages: 1459-1461
ISSN:1538-7755
DOI:10.1158/1055-9965.EPI-17-0191
Online Access:Verlag, Pay-per-use, Volltext: http://dx.doi.org/10.1158/1055-9965.EPI-17-0191
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Author Notes:José Manuel Ordóñez-Mena, Ben Schöttker, Kai U. Saum, Bernd Holleczek, Barbara Burwinkel, Thomas J. Wang, and Hermann Brenner
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Summary:Background: Several investigations assessed the association of vitamin D receptor (VDR) SNPs with cancer risk. Less is known about the implications of other vitamin D pathway SNPs on cancer risk. Methods: In a population-based cohort study of 9,949 German older adults, we used Cox regression to assess the association of 6 SNPs in the VDR, vitamin D-binding protein (GC), 7-dehydrocholesterol reductase (DHCR7), vitamin D 25-hydroxylase (CYP2R1), and vitamin D 24-hydroxylase (CYP24A1) genes with total and site-specific cancer incidence endpoints. Results: Overall, no association of SNPs with cancer incidence endpoints was observed, except for a genotype score based on SNPs associated with lower 25(OH)D, which was associated with higher lung cancer risk [HR, 1.20; 95% confidence intervals (CI), 1.03-1.39], although this was no longer significant after correcting for multiple testing. Conclusions: Our data provide little to no evidence of a major influence of vitamin D genetic predisposition on cancer risks. Impact: Large-scale genetic epidemiology consortia and meta-analysis of smaller published studies are needed to verify a potential modest influence of genetic variation in the association of vitamin D with the risk of cancer.
Item Description:Gesehen am 05.10.2017
Physical Description:Online Resource
ISSN:1538-7755
DOI:10.1158/1055-9965.EPI-17-0191

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