No association of Vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults
Background: Several investigations assessed the association of vitamin D receptor (VDR) SNPs with cancer risk. Less is known about the implications of other vitamin D pathway SNPs on cancer risk. Methods: In a population-based cohort study of 9,949 German older adults, we used Cox regression to asse...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 2017
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| In: |
Cancer epidemiology, biomarkers & prevention
Year: 2017, Jahrgang: 26, Heft: 9, Pages: 1459-1461 |
| ISSN: | 1538-7755 |
| DOI: | 10.1158/1055-9965.EPI-17-0191 |
| Online-Zugang: | Verlag, Pay-per-use, Volltext: http://dx.doi.org/10.1158/1055-9965.EPI-17-0191
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| Verfasserangaben: | José Manuel Ordóñez-Mena, Ben Schöttker, Kai U. Saum, Bernd Holleczek, Barbara Burwinkel, Thomas J. Wang, and Hermann Brenner |
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| 245 | 1 | 0 | |a No association of Vitamin D pathway genetic variants with cancer risks in a population-based cohort of German older adults |c José Manuel Ordóñez-Mena, Ben Schöttker, Kai U. Saum, Bernd Holleczek, Barbara Burwinkel, Thomas J. Wang, and Hermann Brenner |
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| 520 | |a Background: Several investigations assessed the association of vitamin D receptor (VDR) SNPs with cancer risk. Less is known about the implications of other vitamin D pathway SNPs on cancer risk. Methods: In a population-based cohort study of 9,949 German older adults, we used Cox regression to assess the association of 6 SNPs in the VDR, vitamin D-binding protein (GC), 7-dehydrocholesterol reductase (DHCR7), vitamin D 25-hydroxylase (CYP2R1), and vitamin D 24-hydroxylase (CYP24A1) genes with total and site-specific cancer incidence endpoints. Results: Overall, no association of SNPs with cancer incidence endpoints was observed, except for a genotype score based on SNPs associated with lower 25(OH)D, which was associated with higher lung cancer risk [HR, 1.20; 95% confidence intervals (CI), 1.03-1.39], although this was no longer significant after correcting for multiple testing. Conclusions: Our data provide little to no evidence of a major influence of vitamin D genetic predisposition on cancer risks. Impact: Large-scale genetic epidemiology consortia and meta-analysis of smaller published studies are needed to verify a potential modest influence of genetic variation in the association of vitamin D with the risk of cancer. | ||
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