Regulatory function of CD4+CD25++ T cells in patients with myasthenia gravis is associated with phenotypic changes and STAT5 signaling: 1,25-Dihydroxyvitamin D3 modulates the suppressor activity
Regulatory T cells were investigated in early-onset (EO) and late-onset (LO) myasthenia gravis patients with anti-acetylcholine receptor antibody (AChR-MG). Alterations in PD-1 and PD-L1 on CD4+CD25++ (Treg) and responder T cells (Tresp, CD4+CD25−) were observed in LOMG patients. GITR was decreased...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 April 2015
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| In: |
Journal of neuroimmunology
Year: 2015, Volume: 281, Pages: 51-60 |
| ISSN: | 1872-8421 |
| DOI: | 10.1016/j.jneuroim.2015.03.008 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.jneuroim.2015.03.008 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0165572815000557 
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| Author Notes: | Mahdi Alahgholi-Hajibehzad, Piraye Oflazer, Fikret Aysal, Hacer Durmuş, Yeşim Gülşen-Parman, Alexander Marx, Feza Deymeer, Güher Saruhan-Direskeneli |
| Summary: | Regulatory T cells were investigated in early-onset (EO) and late-onset (LO) myasthenia gravis patients with anti-acetylcholine receptor antibody (AChR-MG). Alterations in PD-1 and PD-L1 on CD4+CD25++ (Treg) and responder T cells (Tresp, CD4+CD25−) were observed in LOMG patients. GITR was decreased on CD4+CD25++ of all patients. Decrease of FOXP3 was associated with lower phosphorylation of STAT5.1,25-dihydroxyvitamin D3 (VitD3) increased suppression in co-culture with a stronger effect in patients by acting possibly both on cell groups. Changes in surface molecules and intracellular pathways contribute to the defects of Treg in non-thymomatous AChR-MG and VitD3 can have modulatory effects. |
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| Item Description: | Gesehen am 02.11.2017 Im Titel sind „+” und "++" hochgestellt |
| Physical Description: | Online Resource |
| ISSN: | 1872-8421 |
| DOI: | 10.1016/j.jneuroim.2015.03.008 |