Coronary CT angiography-derived fractional flow reserve correlated with invasive fractional flow reserve measurements: initial experience with a novel physician-driven algorithm
Objectives: The present study aimed to determine the feasibility of a novel fractional flow reserve (FFR) algorithm based on coronary CT angiography (cCTA) that permits point-of-care assessment, without data transfer to core laboratories, for the evaluation of potentially ischemia-causing stenoses....
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 November 2014
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| In: |
European radiology
Year: 2014, Volume: 25, Issue: 4, Pages: 1201-1207 |
| ISSN: | 1432-1084 |
| DOI: | 10.1007/s00330-014-3482-5 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/s00330-014-3482-5 Verlag, Volltext: https://link-springer-com.ezproxy.medma.uni-heidelberg.de/article/10.1007/s00330-014-3482-5 
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| Author Notes: | Stefan Baumann, Rui Wang, U. Joseph Schoepf, Daniel H. Steinberg, James V. Spearman, Richard R. Bayer, Christian W. Hamm, Matthias Renker |
| Summary: | Objectives: The present study aimed to determine the feasibility of a novel fractional flow reserve (FFR) algorithm based on coronary CT angiography (cCTA) that permits point-of-care assessment, without data transfer to core laboratories, for the evaluation of potentially ischemia-causing stenoses. Methods: To obtain CT-based FFR, anatomical coronary information and ventricular mass extracted from cCTA datasets were integrated with haemodynamic parameters. CT-based FFR was assessed for 36 coronary artery stenoses in 28 patients in a blinded fashion and compared to catheter-based FFR. Haemodynamically relevant stenoses were defined by an invasive FFR ≤0.80. Time was measured for the processing of each cCTA dataset and CT-based FFR computation. Assessment of cCTA image quality was performed using a 5-point scale. Results: Mean total time for CT-based FFR determination was 51.9 ± 9.0 min. Per-vessel analysis for the identification of lesion-specific myocardial ischemia demonstrated good correlation (Pearson’s product-moment r = 0.74, p < 0.0001) between the prototype CT-based FFR algorithm and invasive FFR. Subjective image quality analysis resulted in a median score of 4 (interquartile ranges, 3-4). Conclusions: Our initial data suggest that the CT-based FFR method for the detection of haemodynamically significant stenoses evaluated in the selected population correlates well with invasive FFR and renders time-efficient point-of-care assessment possible. |
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| Item Description: | Gesehen am 02.11.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1432-1084 |
| DOI: | 10.1007/s00330-014-3482-5 |