31P RINEPT MRSI and VBM reveal alterations in brain aging associated with major depression
Purpose: Phosphomono- and diesters, the major components of the choline peak in 1H magnetic resonance spectroscopy, are associated with membrane anabolic and catabolic mechanisms. With the refocused insensitive nuclei-enhanced polarization transfer technique, these phospholipids are edited and enhan...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 May 2014
|
| In: |
Magnetic resonance in medicine
Year: 2014, Volume: 73, Issue: 4, Pages: 1390-1400 |
| ISSN: | 1522-2594 |
| DOI: | 10.1002/mrm.25278 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1002/mrm.25278 Verlag, Volltext: http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1002/mrm.25278/abstract 
|
| Author Notes: | Sarah V. Biedermann, Wolfgang Weber-Fahr, Traute Demirakca, Nuran Tunc-Skarka, Mareen Hoerst, Fritz Henn, Alexander Sartorius, and Gabriele Ende |
| Summary: | Purpose: Phosphomono- and diesters, the major components of the choline peak in 1H magnetic resonance spectroscopy, are associated with membrane anabolic and catabolic mechanisms. With the refocused insensitive nuclei-enhanced polarization transfer technique, these phospholipids are edited and enhanced in the 31P MR spectrum. In depressed patients, alterations of the choline peak and cerebral volume have been found, indicating a possible relation. Thus, combining MR phosphorous spectroscopy and volumetry in depressed patients seems to be a promising approach to detect underlying pathomechanisms. Methods: Depressed in-patients were either treated with antidepressive medication or with electroconvulsive therapy and compared to matched healthy controls. 31P magnetic resonance spectroscopy imaging was conducted before and after the treatment phases. A 3D MRI dataset for volumetry was acquired in a dedicated 1H head coil. Results: Phosphocholine and phosphoethanolamine were increased in depressed patients. Though patients responded to the treatments, phospholipids were not significantly altered. An increased age-related gray matter loss in fronto-limbic regions along with an altered relation of phosphomonoesters/phosphodiesters with age were found in depressed patients. Discussion: The findings of increased phosphomonoesthers and an age*group interaction for gray matter volumes need further research to define the role of phospholipids in major depression and possible associations to gray matter loss. |
|---|---|
| Item Description: | Gesehen am 02.11.2017 Im Titel ist „31” hochgestellt |
| Physical Description: | Online Resource |
| ISSN: | 1522-2594 |
| DOI: | 10.1002/mrm.25278 |