31P RINEPT MRSI and VBM reveal alterations in brain aging associated with major depression
Purpose: Phosphomono- and diesters, the major components of the choline peak in 1H magnetic resonance spectroscopy, are associated with membrane anabolic and catabolic mechanisms. With the refocused insensitive nuclei-enhanced polarization transfer technique, these phospholipids are edited and enhan...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 May 2014
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| In: |
Magnetic resonance in medicine
Year: 2014, Volume: 73, Issue: 4, Pages: 1390-1400 |
| ISSN: | 1522-2594 |
| DOI: | 10.1002/mrm.25278 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1002/mrm.25278 Verlag, Volltext: http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1002/mrm.25278/abstract 
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| Author Notes: | Sarah V. Biedermann, Wolfgang Weber-Fahr, Traute Demirakca, Nuran Tunc-Skarka, Mareen Hoerst, Fritz Henn, Alexander Sartorius, and Gabriele Ende |
MARC
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| 245 | 1 | 0 | |a 31P RINEPT MRSI and VBM reveal alterations in brain aging associated with major depression |c Sarah V. Biedermann, Wolfgang Weber-Fahr, Traute Demirakca, Nuran Tunc-Skarka, Mareen Hoerst, Fritz Henn, Alexander Sartorius, and Gabriele Ende |
| 246 | 3 | 0 | |a P-31 RINEPT MRSI and VBM reveal alterations in brain aging associated with major depression |
| 264 | 1 | |c 5 May 2014 | |
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| 520 | |a Purpose: Phosphomono- and diesters, the major components of the choline peak in 1H magnetic resonance spectroscopy, are associated with membrane anabolic and catabolic mechanisms. With the refocused insensitive nuclei-enhanced polarization transfer technique, these phospholipids are edited and enhanced in the 31P MR spectrum. In depressed patients, alterations of the choline peak and cerebral volume have been found, indicating a possible relation. Thus, combining MR phosphorous spectroscopy and volumetry in depressed patients seems to be a promising approach to detect underlying pathomechanisms. Methods: Depressed in-patients were either treated with antidepressive medication or with electroconvulsive therapy and compared to matched healthy controls. 31P magnetic resonance spectroscopy imaging was conducted before and after the treatment phases. A 3D MRI dataset for volumetry was acquired in a dedicated 1H head coil. Results: Phosphocholine and phosphoethanolamine were increased in depressed patients. Though patients responded to the treatments, phospholipids were not significantly altered. An increased age-related gray matter loss in fronto-limbic regions along with an altered relation of phosphomonoesters/phosphodiesters with age were found in depressed patients. Discussion: The findings of increased phosphomonoesthers and an age*group interaction for gray matter volumes need further research to define the role of phospholipids in major depression and possible associations to gray matter loss. | ||
| 534 | |c 2014 | ||
| 650 | 4 | |a electroconvulsive therapy | |
| 650 | 4 | |a Hippocampus | |
| 650 | 4 | |a major depression | |
| 650 | 4 | |a phosphorous magnetic resonance spectroscopy | |
| 650 | 4 | |a refocused insensitive nuclei-enhanced polarization transfer | |
| 650 | 4 | |a voxel based morphometry | |
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| 700 | 1 | |a Ende, Gabriele |e VerfasserIn |0 (DE-588)1031974105 |0 (DE-627)737671734 |0 (DE-576)379696886 |4 aut | |
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