Cover Image

Incremental value of biomarker combinations to predict progression of mild cognitive impairment to Alzheimer’s dementia

Show other versions (1)

The progression of mild cognitive impairment (MCI) to Alzheimer’s disease (AD) dementia can be predicted by cognitive, neuroimaging, and cerebrospinal fluid (CSF) markers. Since most biomarkers reveal complementary information, a combination of biomarkers may increase the predictive power. We invest...

Full description

Saved in:
Bibliographic Details
Main Authors: Frölich, Lutz (Author) , Schröder, Johannes (Author) , Henn, Fritz A. (Author)
Format: Article (Journal)
Language:English
Published: 10 October 2017
In: Alzheimer's research & therapy
Year: 2017, Volume: 9
ISSN:1758-9193
DOI:10.1186/s13195-017-0301-7
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13195-017-0301-7
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13195-017-0301-7
Get full text
Author Notes:Lutz Frölich, Oliver Peters, Piotr Lewczuk, Oliver Gruber, Stefan J. Teipel, Hermann J. Gertz, Holger Jahn, Frank Jessen, Alexander Kurz, Christian Luckhaus, Michael Hüll, Johannes Pantel, Friedel M. Reischies, Johannes Schröder, Michael Wagner, Otto Rienhoff, Stefanie Wolf, Chris Bauer, Johannes Schuchhardt, Isabella Heuser, Eckart Rüther, Fritz Henn, Wolfgang Maier, Jens Wiltfang and Johannes Kornhuber
Description
Summary:The progression of mild cognitive impairment (MCI) to Alzheimer’s disease (AD) dementia can be predicted by cognitive, neuroimaging, and cerebrospinal fluid (CSF) markers. Since most biomarkers reveal complementary information, a combination of biomarkers may increase the predictive power. We investigated which combination of the Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR)-sum-of-boxes, the word list delayed free recall from the Consortium to Establish a Registry of Dementia (CERAD) test battery, hippocampal volume (HCV), amyloid-beta1-42 (Aβ42), amyloid-beta1-40 (Aβ40) levels, the ratio of Aβ42/Aβ40, phosphorylated tau, and total tau (t-Tau) levels in the CSF best predicted a short-term conversion from MCI to AD dementia.
Item Description:Gesehen am 09.11.2017
Physical Description:Online Resource
ISSN:1758-9193
DOI:10.1186/s13195-017-0301-7

Similar Items