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Identification of an epigenetic biomarker predicting the response to therapy with APG101 in glioblastoma

© The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissionsoup.com.Background: APG101, a fully human fusion protein consisting of the extracellular domain of CD95 and the Fc-d...

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Bibliographic Details
Main Authors: Thiemann, Markus (Author) , Wiestler, Benedikt (Author) , Wick, Wolfgang (Author)
Format: Article (Journal)
Language:English
Published: 11 October 2016
In: Annals of oncology
Year: 2016, Volume: 27
ISSN:1569-8041
DOI:10.1093/annonc/mdw363.81
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1093/annonc/mdw363.81
Verlag, kostenfrei, Volltext: https://academic.oup.com/annonc/article/27/suppl_6/133P/2798859
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Author Notes:M. Thiemann, C. Gieffers, C. Kunz, J. Sykora, C. Merz, H. Fricke, B. Wiestler, W. Wick
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Summary:© The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissionsoup.com.Background: APG101, a fully human fusion protein consisting of the extracellular domain of CD95 and the Fc-domain of an IgG, has been developed by Apogenix. It was confirmed as a potent inhibitor of CD95L induced invasion of glioblastoma cells in vitro. In a randomized phase 2 study in glioblastoma patients with 1st or 2nd relapse the combined therapy of APG101 plus radiotherapy (RT) was found to be superior to RT alone in a clinically relevant order of magnitude in all efficacy endpoints (i.e. PFS-6, PFS and OS). At the same time APG101 exhibited an excellent safety profile and was well tolerated. The presented data summarizes the identification of a predictive biomarker.Methods: To identify potential biomarkers we used available tissue sections originating...
Item Description:Gesehen am 15.11.2017
Physical Description:Online Resource
ISSN:1569-8041
DOI:10.1093/annonc/mdw363.81

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