Minocycline exacerbates apoptotic neurodegeneration induced by the NMDA receptor antagonist MK-801 in the early postnatal mouse brain
NMDA receptor (NMDAR) antagonists induce in perinatal rodent cortical apoptosis and protracted schizophrenia-like alterations ameliorated by antipsychotic treatment. The broad-spectrum antibiotic minocycline elicits antipsychotic and neuroprotective effects. Here we tested, if minocycline protects a...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2016
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| In: |
European archives of psychiatry and clinical neuroscience
Year: 2015, Volume: 266, Issue: 7, Pages: 673-677 |
| ISSN: | 1433-8491 |
| DOI: | 10.1007/s00406-015-0649-2 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/s00406-015-0649-2 Verlag, Volltext: https://link.springer.com/article/10.1007/s00406-015-0649-2 
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| Author Notes: | Ioana Inta, Miriam A. Vogt, Anne S. Vogel, Markus Bettendorf, Peter Gass, Dragos Inta |
| Summary: | NMDA receptor (NMDAR) antagonists induce in perinatal rodent cortical apoptosis and protracted schizophrenia-like alterations ameliorated by antipsychotic treatment. The broad-spectrum antibiotic minocycline elicits antipsychotic and neuroprotective effects. Here we tested, if minocycline protects also against apoptosis triggered by the NMDAR antagonist MK-801 at postnatal day 7. Surprisingly, minocycline induced widespread cortical apoptosis and exacerbated MK-801-triggered cell death. In some areas such as the subiculum, the pro-apoptotic effect of minocycline was even more pronounced than that elicited by MK-801. These data reveal among antipsychotics unique pro-apoptotic properties of minocycline, raising concerns regarding consequences for brain development and the use in children. |
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| Item Description: | First Online: 19 October 2015 Gesehen am 29.11.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1433-8491 |
| DOI: | 10.1007/s00406-015-0649-2 |