An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice

Cancer cachexia is marked by a pathological loss of fat tissue, but preventing the degradation of AMPK in this tissue helps preserve its mass in mouse models.

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Bibliographic Details
Main Authors:	Rohm, Maria (Author) , Schäfer, Michaela (Author) , Laurent, Victor (Author) , Üstünel, Bilgen Ekim (Author) , Niopek, Katharina (Author) , Algire, Carolyn (Author) , Hautzinger, Oksana (Author) , Sijmonsma, Tjeerd P. (Author) , Zota, Annika (Author) , Medrikova, Dasa (Author) , Pellegata, Natalia Simona (Author) , Berriel Diaz, Mauricio (Author) , Herzig, Stephan (Author)
Format:	Article (Journal)
Language:	English
Published:	29 August 2016
In:	Nature medicine Year: 2016, Volume: 22, Issue: 10, Pages: 1120-1130
ISSN:	1546-170X
DOI:	10.1038/nm.4171
Online Access:	Verlag, Volltext: http://dx.doi.org/10.1038/nm.4171 Verlag, Volltext: https://www.nature.com/articles/nm.4171
Author Notes:	Maria Rohm, Michaela Schäfer, Victor Laurent, Bilgen Ekim Üstünel, Katharina Niopek, Carolyn Algire, Oksana Hautzinger, Tjeerd P. Sijmonsma, Annika Zota, Dasa Medrikova, Natalia S. Pellegata, Mikael Ryden, Agné Kulyte, Ingrid Dahlman, Peter Arner, Natasa Petrovic, Barbara Cannon, Ez-Zoubir Amri, Bruce E. Kemp, Gregory R. Steinberg, Petra Janovska, Jan Kopecky, Christian Wolfrum, Matthias Blüher, Mauricio Berriel Diaz, Stephan Herzig

Description
Summary:	Cancer cachexia is marked by a pathological loss of fat tissue, but preventing the degradation of AMPK in this tissue helps preserve its mass in mouse models.
Item Description:	Gesehen am 29.11.2017
Physical Description:	Online Resource
ISSN:	1546-170X
DOI:	10.1038/nm.4171