An AMP-activated protein kinase-stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice
Cancer cachexia is marked by a pathological loss of fat tissue, but preventing the degradation of AMPK in this tissue helps preserve its mass in mouse models.
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 August 2016
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| In: |
Nature medicine
Year: 2016, Jahrgang: 22, Heft: 10, Pages: 1120-1130 |
| ISSN: | 1546-170X |
| DOI: | 10.1038/nm.4171 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1038/nm.4171 Verlag, Volltext: https://www.nature.com/articles/nm.4171 |
| Verfasserangaben: | Maria Rohm, Michaela Schäfer, Victor Laurent, Bilgen Ekim Üstünel, Katharina Niopek, Carolyn Algire, Oksana Hautzinger, Tjeerd P. Sijmonsma, Annika Zota, Dasa Medrikova, Natalia S. Pellegata, Mikael Ryden, Agné Kulyte, Ingrid Dahlman, Peter Arner, Natasa Petrovic, Barbara Cannon, Ez-Zoubir Amri, Bruce E. Kemp, Gregory R. Steinberg, Petra Janovska, Jan Kopecky, Christian Wolfrum, Matthias Blüher, Mauricio Berriel Diaz, Stephan Herzig |
| Zusammenfassung: | Cancer cachexia is marked by a pathological loss of fat tissue, but preventing the degradation of AMPK in this tissue helps preserve its mass in mouse models. |
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| Beschreibung: | Gesehen am 29.11.2017 |
| Beschreibung: | Online Resource |
| ISSN: | 1546-170X |
| DOI: | 10.1038/nm.4171 |