Insights into light-driven DNA repair by photolyases: challenges and opportunities for electronic structure theory
Ultraviolet radiation causes two of the most abundant mutagenic and cytotoxic DNA lesions: cyclobutane pyrimidine dimers and 6-4 photoproducts. (6-4) Photolyases are light-activated enzymes that selectively bind to DNA and trigger repair of mutagenic 6-4 photoproducts via photoinduced electron trans...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 January 2017
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| In: |
Photochemistry and photobiology
Year: 2017, Volume: 93, Issue: 1, Pages: 37-50 |
| ISSN: | 1751-1097 |
| DOI: | 10.1111/php.12679 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1111/php.12679 Verlag, Volltext: http://onlinelibrary.wiley.com/doi/10.1111/php.12679/abstract 
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| Author Notes: | Shirin Faraji and Andreas Dreuw |
| Summary: | Ultraviolet radiation causes two of the most abundant mutagenic and cytotoxic DNA lesions: cyclobutane pyrimidine dimers and 6-4 photoproducts. (6-4) Photolyases are light-activated enzymes that selectively bind to DNA and trigger repair of mutagenic 6-4 photoproducts via photoinduced electron transfer from flavin adenine dinucleotide anion (FADH−) to the lesion triggering repair. This review provides an overview of the sequential steps of the repair process, that is light absorption and resonance energy transfer, photoinduced electron transfer and electron-induced splitting mechanisms, with an emphasis on the role of theory and computation. In addition, theoretical calculations and physical properties that can be used to classify specific mechanism are discussed in an effort to trace the fundamental aspects of each individual step and assist the interpretation of experimental data. The current challenges and suggested future directions are outlined for each step, concluding with a view on the future. |
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| Item Description: | Gesehen am 01.12.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1751-1097 |
| DOI: | 10.1111/php.12679 |