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Comparison of livestock-associated and health care-associated MRSA: genes, virulence, and resistance

Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) may colonize and infect humans with close contact to pigs. We compared phenotypic and genotypic differences in resistance and virulence of LA-MRSA isolates from farms and farmers with hospital-acquired methicillin-resistant S...

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Bibliographic Details
Main Authors: Mutters, Nico T. (Author) , Bieber, Christian Paul (Author) , Hauck, Catherine (Author) , Malek, Veronika (Author) , Frank, Uwe (Author)
Format: Article (Journal)
Language:English
Published: 26 August 2016
In: Diagnostic microbiology and infectious disease
Year: 2016, Volume: 86, Issue: 4, Pages: 417-421
ISSN:1879-0070
DOI:10.1016/j.diagmicrobio.2016.08.016
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.diagmicrobio.2016.08.016
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0732889316302553
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Author Notes:Nico T. Mutters, Christian P. Bieber, Catherine Hauck, Gerald Reiner, Veronika Malek, Uwe Frank
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Summary:Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) may colonize and infect humans with close contact to pigs. We compared phenotypic and genotypic differences in resistance and virulence of LA-MRSA isolates from farms and farmers with hospital-acquired methicillin-resistant S. aureus (HA-MRSA) and assessed carriage rates. Samples from pigs (n=330), occupationally exposed personnel (n=63), the farm environment (n=134), and hospital patients (n=220) were obtained. Approximately 50% (166/330) of pigs were MRSA positive. All LA-MRSA were resistant to tetracycline, compared to only 8% of HA-MRSA (P<0.001). In contrast, HA-MRSA isolates showed significantly higher resistance rates to quinolones (81% versus 7%; P<0.001). All strains isolated from occupationally exposed personnel (61.9%; 39/63) belonged to CC398. HA-MRSA isolates were diversely distributed, with predominance of CC5 (62.7%). Human strains carried significantly more virulence genes than porcine strains, especially exotoxins (P<0.001) and immune-evasion cluster genes (P<0.001). There were significant differences in resistance patterns and recognized genotypic virulence loci between LA-MRSA and HA-MRSA.
Item Description:Gesehen am 05.12.2017
Physical Description:Online Resource
ISSN:1879-0070
DOI:10.1016/j.diagmicrobio.2016.08.016

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