68Ga-PSMA-11 dynamic PET/CT imaging in primary prostate cancer
The aim of our study is to assess the pharmacokinetics and biodistribution of 68Ga-PSMA-11 in patients suffering from primary prostate cancer (PC) by means of dynamic and whole-body PET/CT. Twenty-four patients with primary, previously untreated PC were enrolled in the study. All patients underwent...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 3, 2016
|
| In: |
Clinical nuclear medicine
Year: 2016, Volume: 41, Issue: 11, Pages: E473-E479 |
| ISSN: | 1536-0229 |
| DOI: | 10.1097/RLU.0000000000001349 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1097/RLU.0000000000001349 Verlag, Volltext: https://insights.ovid.com/pubmed?pmid=27607173 
|
| Author Notes: | Christos Sachpekidis, MD, Klaus Kopka, PhD, Matthias Eder, PhD, Boris A. Hadaschik, MD, Martin T. Freitag, MD, Leyun Pan, PhD, Uwe Haberkorn, MD, Antonia Dimitrakopoulou-Strauss, MD |
| Summary: | The aim of our study is to assess the pharmacokinetics and biodistribution of 68Ga-PSMA-11 in patients suffering from primary prostate cancer (PC) by means of dynamic and whole-body PET/CT. Twenty-four patients with primary, previously untreated PC were enrolled in the study. All patients underwent dynamic PET/CT (dPET/CT) scanning of the pelvis and whole-body PET/CT studies with 68Ga-PSMA-11. The evaluation of dPET/CT studies was based on qualitative evaluation, SUV calculation, and quantitative analysis based on two-tissue compartment modeling and a noncompartmental approach leading to the extraction of fractal dimension (FD). A total of 23/24 patients (95.8%) were 68Ga-PSMA-11 positive. In 9/24 patients (37.5%), metastatic lesions were detected. PC-associated lesions demonstrated the following mean values: SUVaverage = 14.3, SUVmax = 23.4, K1 = 0.24 (1/min), k3 = 0.34 (1/min), influx = 0.15 (1/min), and FD = 1.27. The parameters SUVaverage, SUVmax, k3, influx, and FD derived from PC-associated lesions were significantly higher than respective values derived from reference prostate tissue. Time-activity curves derived from PC-associated lesions revealed an increasing 68Ga-PSMA-11 accumulation during dynamic PET acquisition. Correlation analysis revealed a moderate but significant correlation between PSA levels and SUVaverage (r = 0.60) and SUVmax (r = 0.57), and a weak but significant correlation between Gleason score and SUVaverage (r = 0.33) and SUVmax (r = 0.28). 68Ga-PSMA-11 PET/CT confirmed its capacity in detecting primary PC with a detection rate of 95.8%. Dynamic PET/CT studies of the pelvis revealed an increase in tracer uptake in PC-associated lesions during the 60 minutes of dynamic PET acquisition, a finding with potential applications in anti-PSMA approaches. |
|---|---|
| Item Description: | Im Titel ist 68 hochgestellt Gesehen am 06.12.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1536-0229 |
| DOI: | 10.1097/RLU.0000000000001349 |