ASS-Intoleranz-Syndrom und persistierende Rhinosinusitis: Differentialdiagnostik und Therapie = ASA-intolerance syndrome and persistent rhinosinusitis
Background: A differential diagnosis of persistent chronic rhinosinusitis is ASA-intolerance syndrome (AIS), also known as Aspirin®‑exacerbated respiratory disease (AERD), Samter-Trias (Samter’s disease, Morbus Widal). Particularly in cases of frequent recurrency of nasal polyps in combination with...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | German |
| Published: |
1. Mai 2015
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| In: |
HNO
Year: 2015, Volume: 63, Issue: 5, Pages: 357-363 |
| ISSN: | 1433-0458 |
| DOI: | 10.1007/s00106-015-0008-7 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/s00106-015-0008-7 Verlag, Volltext: https://link.springer.com/article/10.1007/s00106-015-0008-7 
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| Author Notes: | H. Kirsche, L. Klimek |
| Summary: | Background: A differential diagnosis of persistent chronic rhinosinusitis is ASA-intolerance syndrome (AIS), also known as Aspirin®‑exacerbated respiratory disease (AERD), Samter-Trias (Samter’s disease, Morbus Widal). Particularly in cases of frequent recurrency of nasal polyps in combination with bronchial asthma and hypersensitivity reactions to acetylsalicylic acid (ASA) and other nonsteroidal anti-inflammatory drugs (NSAR) can often be referred to an underlying AIS. The pathogenesis of this syndrome is attributed to a misallocation of the arachidonic acid metabolism, resulting in an increased leukotriene production. Methods: The diagnosis may be difficult in the early stages of the disease with incomplete triad of symptoms. Results: Therapy may consist of paranasal sinuses surgery, drug therapy and adaptive deactivation as the only causal treatment option for patients with AIS. Conclusion: For adaptive desactivation, positive effects were actually shown even in patients with long-term recurrent or persistent complaints of chronic rhinosinusitis. |
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| Item Description: | Gesehen am 06.12.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1433-0458 |
| DOI: | 10.1007/s00106-015-0008-7 |