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ASS-Intoleranz-Syndrom und persistierende Rhinosinusitis: Differentialdiagnostik und Therapie = ASA-intolerance syndrome and persistent rhinosinusitis

Background: A differential diagnosis of persistent chronic rhinosinusitis is ASA-intolerance syndrome (AIS), also known as Aspirin®‑exacerbated respiratory disease (AERD), Samter-Trias (Samter’s disease, Morbus Widal). Particularly in cases of frequent recurrency of nasal polyps in combination with...

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Bibliographic Details
Main Authors: Kirsche, Hanspeter (Author) , Klimek, Ludger (Author)
Format: Article (Journal)
Language:German
Published: 1. Mai 2015
In: HNO
Year: 2015, Volume: 63, Issue: 5, Pages: 357-363
ISSN:1433-0458
DOI:10.1007/s00106-015-0008-7
Online Access:Verlag, Volltext: http://dx.doi.org/10.1007/s00106-015-0008-7
Verlag, Volltext: https://link.springer.com/article/10.1007/s00106-015-0008-7
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Author Notes:H. Kirsche, L. Klimek

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520 |a Background: A differential diagnosis of persistent chronic rhinosinusitis is ASA-intolerance syndrome (AIS), also known as Aspirin®‑exacerbated respiratory disease (AERD), Samter-Trias (Samter’s disease, Morbus Widal). Particularly in cases of frequent recurrency of nasal polyps in combination with bronchial asthma and hypersensitivity reactions to acetylsalicylic acid (ASA) and other nonsteroidal anti-inflammatory drugs (NSAR) can often be referred to an underlying AIS. The pathogenesis of this syndrome is attributed to a misallocation of the arachidonic acid metabolism, resulting in an increased leukotriene production. Methods: The diagnosis may be difficult in the early stages of the disease with incomplete triad of symptoms. Results: Therapy may consist of paranasal sinuses surgery, drug therapy and adaptive deactivation as the only causal treatment option for patients with AIS. Conclusion: For adaptive desactivation, positive effects were actually shown even in patients with long-term recurrent or persistent complaints of chronic rhinosinusitis. 
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