Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors
Spatial patterning of biochemical cues on the micro- and nanometer scale controls numerous cellular processes such as spreading, adhesion, migration, and proliferation. Using force microscopy we show that the lateral spacing of individual integrin receptor-ligand bonds determines the strength of cel...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 February 2010
|
| In: |
Biophysical journal
Year: 2010, Jahrgang: 98, Heft: 4, Pages: 543-551 |
| ISSN: | 1542-0086 |
| DOI: | 10.1016/j.bpj.2009.11.001 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.bpj.2009.11.001 Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S0006349509016890 
|
| Verfasserangaben: | C. Selhuber-Unkel, T. Erdmann, M. López-García, H. Kessler, U.S. Schwarz, and J.P. Spatz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1566179491 | ||
| 003 | DE-627 | ||
| 005 | 20220814041254.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 171208s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.bpj.2009.11.001 |2 doi | |
| 035 | |a (DE-627)1566179491 | ||
| 035 | |a (DE-576)496179497 | ||
| 035 | |a (DE-599)BSZ496179497 | ||
| 035 | |a (OCoLC)1340983169 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 29 |2 sdnb | ||
| 100 | 1 | |a Selhuber-Unkel, Christine |d 1980- |e VerfasserIn |0 (DE-588)132414759 |0 (DE-627)522682626 |0 (DE-576)299131491 |4 aut | |
| 245 | 1 | 0 | |a Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors |c C. Selhuber-Unkel, T. Erdmann, M. López-García, H. Kessler, U.S. Schwarz, and J.P. Spatz |
| 264 | 1 | |c 11 February 2010 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.12.2017 | ||
| 520 | |a Spatial patterning of biochemical cues on the micro- and nanometer scale controls numerous cellular processes such as spreading, adhesion, migration, and proliferation. Using force microscopy we show that the lateral spacing of individual integrin receptor-ligand bonds determines the strength of cell adhesion. For spacings ≥90 nm, focal contact formation was inhibited and the detachment forces as well as the stiffness of the cell body were significantly decreased compared to spacings ≤50 nm. Analyzing cell detachment at the subcellular level revealed that rupture forces of focal contacts increase with loading rate as predicted by a theoretical model for adhesion clusters. Furthermore, we show that the weak link between the intra- and extracellular space is at the intracellular side of a focal contact. Our results show that cells can amplify small differences in adhesive cues to large differences in cell adhesion strength. | ||
| 700 | 1 | |a Erdmann, Thorsten |e VerfasserIn |0 (DE-588)1148013814 |0 (DE-627)1007492732 |0 (DE-576)496142070 |4 aut | |
| 700 | 1 | |a Schwarz, Ulrich S. |d 1966- |e VerfasserIn |0 (DE-588)120379473 |0 (DE-627)080637280 |0 (DE-576)297582763 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biophysical journal |d Cambridge, Mass. : Cell Press, 1960 |g 98(2010), 4, Seite 543-551 |h Online-Ressource |w (DE-627)270425357 |w (DE-600)1477214-0 |w (DE-576)091017602 |x 1542-0086 |7 nnas |a Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors |
| 773 | 1 | 8 | |g volume:98 |g year:2010 |g number:4 |g pages:543-551 |g extent:9 |a Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.bpj.2009.11.001 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0006349509016890 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20171208 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 120379473 |a Schwarz, Ulrich S. |m 120379473:Schwarz, Ulrich S. |d 130000 |d 130300 |e 130000PS120379473 |e 130300PS120379473 |k 0/130000/ |k 1/130000/130300/ |p 5 | ||
| 998 | |g 1148013814 |a Erdmann, Thorsten |m 1148013814:Erdmann, Thorsten |d 130000 |d 130300 |e 130000PE1148013814 |e 130300PE1148013814 |k 0/130000/ |k 1/130000/130300/ |p 2 | ||
| 998 | |g 132414759 |a Selhuber-Unkel, Christine |m 132414759:Selhuber-Unkel, Christine |p 1 |x j | ||
| 999 | |a KXP-PPN1566179491 |e 2989556842 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Selhuber-Unkel","role":"aut","display":"Selhuber-Unkel, Christine","given":"Christine"},{"family":"Erdmann","role":"aut","display":"Erdmann, Thorsten","given":"Thorsten"},{"given":"Ulrich S.","family":"Schwarz","role":"aut","display":"Schwarz, Ulrich S."}],"id":{"eki":["1566179491"],"doi":["10.1016/j.bpj.2009.11.001"]},"origin":[{"dateIssuedDisp":"11 February 2010","dateIssuedKey":"2010"}],"title":[{"title":"Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors","title_sort":"Cell adhesion strength is controlled by intermolecular spacing of adhesion receptors"}],"name":{"displayForm":["C. Selhuber-Unkel, T. Erdmann, M. López-García, H. Kessler, U.S. Schwarz, and J.P. Spatz"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"9 S."}],"recId":"1566179491","relHost":[{"corporate":[{"display":"Biophysical Society","role":"isb"}],"note":["Gesehen am 20.05.2020"],"recId":"270425357","physDesc":[{"extent":"Online-Ressource"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"titleAlt":[{"title":"BJ"}],"language":["eng"],"pubHistory":["1.1960/61 -"],"name":{"displayForm":["ed. by the Biophysical Society"]},"title":[{"title":"Biophysical journal","title_sort":"Biophysical journal","subtitle":"BJ"}],"disp":"Cell adhesion strength is controlled by intermolecular spacing of adhesion receptorsBiophysical journal","part":{"pages":"543-551","text":"98(2010), 4, Seite 543-551","year":"2010","volume":"98","extent":"9","issue":"4"},"id":{"zdb":["1477214-0"],"eki":["270425357"],"issn":["1542-0086"]},"origin":[{"publisher":"Cell Press ; Soc. ; Rockefeller Univ. Press","publisherPlace":"Cambridge, Mass. ; Bethesda, Md. ; New York, NY","dateIssuedKey":"1960","dateIssuedDisp":"1960-"}]}],"language":["eng"],"note":["Gesehen am 08.12.2017"]} | ||
| SRT | |a SELHUBERUNCELLADHESI1120 | ||