Impact of receptor-ligand distance on adhesion cluster stability
Cells in multicellular organisms adhere to the extracellular matrix through two-dimensional clusters spanning a size range from very few to thousands of adhesion bonds. For many common receptor-ligand systems, the ligands are tethered to a surface via polymeric spacers with finite binding range, thu...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
09 March 2007
|
| In: |
The European physical journal. E, Soft matter
Year: 2007, Volume: 22, Issue: 2, Pages: 123-137 |
| ISSN: | 1292-895X |
| DOI: | 10.1140/epje/e2007-00019-8 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1140/epje/e2007-00019-8 Verlag, Volltext: https://link.springer.com/article/10.1140/epje/e2007-00019-8 
|
| Author Notes: | T. Erdmann and U.S. Schwarz |
| Summary: | Cells in multicellular organisms adhere to the extracellular matrix through two-dimensional clusters spanning a size range from very few to thousands of adhesion bonds. For many common receptor-ligand systems, the ligands are tethered to a surface via polymeric spacers with finite binding range, thus adhesion cluster stability crucially depends on receptor-ligand distance. We introduce a one-step master equation which incorporates the effect of cooperative binding through a finite number of polymeric ligand tethers. We also derive Fokker-Planck and mean field equations as continuum limits of the master equation. Polymers are modeled either as harmonic springs or as worm-like chains. In both cases, we find bistability between bound and unbound states for intermediate values of receptor-ligand distance and calculate the corresponding switching times. For small cluster sizes, stochastic effects destabilize the clusters at large separation, as shown by a detailed analysis of the stochastic potential resulting from the Fokker-Planck equation. |
|---|---|
| Item Description: | Gesehen am 12.12.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1292-895X |
| DOI: | 10.1140/epje/e2007-00019-8 |