Impact of receptor-ligand distance on adhesion cluster stability
Cells in multicellular organisms adhere to the extracellular matrix through two-dimensional clusters spanning a size range from very few to thousands of adhesion bonds. For many common receptor-ligand systems, the ligands are tethered to a surface via polymeric spacers with finite binding range, thu...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
09 March 2007
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| In: |
The European physical journal. E, Soft matter
Year: 2007, Jahrgang: 22, Heft: 2, Pages: 123-137 |
| ISSN: | 1292-895X |
| DOI: | 10.1140/epje/e2007-00019-8 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1140/epje/e2007-00019-8 Verlag, Volltext: https://link.springer.com/article/10.1140/epje/e2007-00019-8 
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| Verfasserangaben: | T. Erdmann and U.S. Schwarz |
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| 520 | |a Cells in multicellular organisms adhere to the extracellular matrix through two-dimensional clusters spanning a size range from very few to thousands of adhesion bonds. For many common receptor-ligand systems, the ligands are tethered to a surface via polymeric spacers with finite binding range, thus adhesion cluster stability crucially depends on receptor-ligand distance. We introduce a one-step master equation which incorporates the effect of cooperative binding through a finite number of polymeric ligand tethers. We also derive Fokker-Planck and mean field equations as continuum limits of the master equation. Polymers are modeled either as harmonic springs or as worm-like chains. In both cases, we find bistability between bound and unbound states for intermediate values of receptor-ligand distance and calculate the corresponding switching times. For small cluster sizes, stochastic effects destabilize the clusters at large separation, as shown by a detailed analysis of the stochastic potential resulting from the Fokker-Planck equation. | ||
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