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A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway

A proteolytically derived fragment of the epigenetic regulator HDAC4 protects the heart through transcriptional repression of the hexosamine biosynthetic pathway, thereby inhibiting protein O-GlcNAcylation and maintaining normal calcium handling and contractility of cardiomyocytes.</p>

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Bibliographic Details
Main Authors: Lehmann, Lorenz (Author) , Jebessa, Zegeye Hailu (Author) , Kreußer, Michael (Author) , Horsch, Axel (Author) , He, Tao (Author) , Kronlage, Mariya (Author) , Dewenter, Matthias (Author) , Sramek, Viviana (Author) , Oehl, Ulrike (Author) , Krebs-Haupenthal, Jutta (Author) , Ritterhoff, Julia (Author) , Finke, Daniel (Author) , Völkers, Mirko (Author) , Jungmann, Andreas (Author) , Sauer, Sven (Author) , Thiel, Christian (Author) , Sticht, Carsten (Author) , Gretz, Norbert (Author) , Camacho Londoño, Juan Eduardo (Author) , Meder, Benjamin (Author) , Freichel, Marc (Author) , Gröne, Hermann-Josef (Author) , Most, Patrick (Author) , Müller, Oliver J. (Author) , Herzig, Stephan (Author) , Furlong, Eileen E. M. (Author) , Katus, Hugo (Author) , Backs, Johannes (Author)
Format: Article (Journal)
Language:English
Published: 2018
In: Nature medicine
Year: 2018, Volume: 24, Issue: 1, Pages: 62-72
ISSN:1546-170X
DOI:10.1038/nm.4452
Online Access:Verlag, Volltext: http://dx.doi.org/10.1038/nm.4452
Verlag, Volltext: https://www.nature.com/articles/nm.4452.pdf
Verlag, Volltext: https://www.nature.com/articles/nm.4452
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Author Notes:Lorenz H. Lehmann, Zegeye H. Jebessa, Michael M. Kreusser, Axel Horsch, Tao He, Mariya Kronlage, Matthias Dewenter, Viviana Sramek, Ulrike Oehl, Jutta Krebs-Haupenthal, Albert H. von der Lieth, Andrea Schmidt, Qiang Sun, Julia Ritterhoff, Daniel Finke, Mirko Völkers, Andreas Jungmann, Sven W. Sauer, Christian Thiel, Alexander Nickel, Michael Kohlhaas, Michaela Schäfer, Carsten Sticht, Christoph Maack, Norbert Gretz, Michael Wagner, Ali El-Armouche, Lars S. Maier, Juan E. Camacho Londoño, Benjamin Meder, Marc Freichel, Hermann-Josef Gröne, Patrick Most, Oliver J. Müller, Stephan Herzig, Eileen E. M. Furlong, Hugo A. Katus, Johannes Backs
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Summary:A proteolytically derived fragment of the epigenetic regulator HDAC4 protects the heart through transcriptional repression of the hexosamine biosynthetic pathway, thereby inhibiting protein O-GlcNAcylation and maintaining normal calcium handling and contractility of cardiomyocytes.</p>
Item Description:Published online 4 December 2017
Gesehen am 11.07.2018
Physical Description:Online Resource
ISSN:1546-170X
DOI:10.1038/nm.4452

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