Hippocampal-dorsolateral prefrontal coupling as a species-conserved cognitive mechanism: a human translational imaging study
Hippocampal–prefrontal cortex (HC–PFC) interactions are implicated in working memory (WM) and altered in psychiatric conditions with cognitive impairment such as schizophrenia. While coupling between both structures is crucial for WM performance in rodents, evidence from human studies is conflicting...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
4 February 2015
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| In: |
Neuropsychopharmacology
Year: 2015, Volume: 40, Issue: 7, Pages: 1674-1681 |
| ISSN: | 1740-634X |
| DOI: | 10.1038/npp.2015.13 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/npp.2015.13 Verlag, Volltext: https://www-nature-com.ezproxy.medma.uni-heidelberg.de/articles/npp201513 
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| Author Notes: | Florian Bähner, Charmaine Demanuele, Janina Schweiger, Martin F. Gerchen, Vera Zamoscik, Kai Ueltzhöffer, Tim Hahn, Patric Meyer, Herta Flor, Daniel Durstewitz, Heike Tost, Peter Kirsch, Michael M. Plichta and Andreas Meyer-Lindenberg |
| Summary: | Hippocampal–prefrontal cortex (HC–PFC) interactions are implicated in working memory (WM) and altered in psychiatric conditions with cognitive impairment such as schizophrenia. While coupling between both structures is crucial for WM performance in rodents, evidence from human studies is conflicting and translation of findings is complicated by the use of differing paradigms across species. We therefore used functional magnetic resonance imaging together with a spatial WM paradigm adapted from rodent research to examine HC–PFC coupling in humans. A PFC–parietal network was functionally connected to hippocampus (HC) during task stages requiring high levels of executive control but not during a matched control condition. The magnitude of coupling in a network comprising HC, bilateral dorsolateral PFC (DLPFC), and right supramarginal gyrus explained one-fourth of the variability in an independent spatial WM task but was unrelated to visual WM performance. HC–DLPFC coupling may thus represent a systems-level mechanism specific to spatial WM that is conserved across species, suggesting its utility for modeling cognitive dysfunction in translational neuroscience. |
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| Item Description: | Gesehen am 14.12.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1740-634X |
| DOI: | 10.1038/npp.2015.13 |