Murine transgenic embryonic stem cell lines for the investigation of sinoatrial node-related molecular pathways
The elucidation of molecular mechanisms that restrict the potential of pluripotent stem cells and promote cardiac lineage differentiation is of crucial relevance, since embryonic stem cells (ESCs) hold great potential for cell based heart therapies. The homeodomain transcription factor Shox2 is esse...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 July 2017
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| In: |
Stem cell research
Year: 2017, Volume: 25, Pages: 278-282 |
| ISSN: | 1876-7753 |
| DOI: | 10.1016/j.scr.2017.07.011 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.scr.2017.07.011 Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S1873506117301356 
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| Author Notes: | Stefanie Schmitteckert, Anne Griesbeck, Simon Sumer, Anna Jauch, Alexandra Rolletschek, Beate Niesler, Gudrun A. Rappold, Sandra Hoffmann |
| Summary: | The elucidation of molecular mechanisms that restrict the potential of pluripotent stem cells and promote cardiac lineage differentiation is of crucial relevance, since embryonic stem cells (ESCs) hold great potential for cell based heart therapies. The homeodomain transcription factor Shox2 is essential for the development and proper function of the native cardiac pacemaker, the sinoatrial node. This prompted us to develop a cardiac differentiation model using ESC lines isolated from blastocysts of Shox2-deficient mice. The established cell model provides a fundamental basis for the investigation of molecular pathways under physiological and pathophysiological conditions for evaluating novel therapeutic approaches. |
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| Item Description: | Gesehen am 21.12.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1876-7753 |
| DOI: | 10.1016/j.scr.2017.07.011 |