Rituximab induces phenotypical and functional changes of NK cells in a non-malignant experimental setting
Rituximab has broad and increasing application in rheumatic diseases. It is known from lymphoma studies that natural killer (NK) cells can lyse rituximab-coated transformed B cells. However, the role of NK cells in mediating rituximab-induced depletion of non-malignant B cells is unknown. The purpos...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
15 September 2016
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| In: |
Arthritis Research & Therapy
Year: 2016, Volume: 18 |
| ISSN: | 1465-9913 |
| DOI: | 10.1186/s13075-016-1101-3 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13075-016-1101-3 Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13075-016-1101-3 
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| Author Notes: | Wolfgang Merkt, Hanns-Martin Lorenz, Carsten Watzl |
| Summary: | Rituximab has broad and increasing application in rheumatic diseases. It is known from lymphoma studies that natural killer (NK) cells can lyse rituximab-coated transformed B cells. However, the role of NK cells in mediating rituximab-induced depletion of non-malignant B cells is unknown. The purpose of this study was to provide fundamental data on rituximab-mediated effects on NK cells in PBMCs without tumor cells, in order to simulate effects that could be relevant in patients with rheumatic disease. |
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| Item Description: | Gesehen am 21.12.2017 |
| Physical Description: | Online Resource |
| ISSN: | 1465-9913 |
| DOI: | 10.1186/s13075-016-1101-3 |