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Integrative genomic and transcriptomic analysis of leiomyosarcoma

The molecular genetic landscape of leiomyosarcoma (LMS) is largely unknown. Here, the authors identify frequent DNA copy number alterations, whole-genome duplication, <i>TP53</i> and <i>RB1</i> inactivation, alternative telomere lengthening, and genomic imprints of defective...

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Main Authors: Chudasama, Priya (Author) , Herbst, Sophie (Author) , Kasper, Bernd (Author) , Heilig, Christoph E. (Author) , Egerer, Gerlinde (Author) , Kalle, Christof von (Author) , Eils, Roland (Author) , Stenzinger, Albrecht (Author) , Glimm, Hanno (Author) , Gröschel, Stefan (Author) , Omlor, Georg (Author) , Lehner, Burkhard (Author) , Schimmack, Simon (Author) , Ulrich, Alexis (Author) , Mechtersheimer, Gunhild (Author) , Rippe, Karsten (Author) , Brors, Benedikt (Author) , Renner, Marcus (Author) , Hohenberger, Peter (Author) , Scholl, Claudia (Author) , Fröhling, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 10 January 2018
In: Nature Communications
Year: 2018, Volume: 9
ISSN:2041-1723
DOI:10.1038/s41467-017-02602-0
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41467-017-02602-0
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-017-02602-0
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-017-02602-0.pdf
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Author Notes:Priya Chudasama, Sadaf S. Mughal, Mathijs A. Sanders, Daniel Hübschmann, Inn Chung, Katharina I. Deeg, Siao-Han Wong, Sophie Rabe, Mario Hlevnjak, Marc Zapatka, Aurélie Ernst, Kortine Kleinheinz, Matthias Schlesner, Lina Sieverling, Barbara Klink, Evelin Schröck, Remco M. Hoogenboezem, Bernd Kasper, Christoph E. Heilig, Gerlinde Egerer, Stephan Wolf, Christof Kalle, Roland Eils, Albrecht Stenzinger, Wilko Weichert, Hanno Glimm, Stefan Gröschel, Hans-Georg Kopp, Georg Omlor, Burkhard Lehner, Sebastian Bauer, Simon Schimmack, Alexis Ulrich, Gunhild Mechtersheimer, Karsten Rippe, Benedikt Brors, Barbara Hutter, Marcus Renner, Peter Hohenberger, Claudia Scholl, Stefan Fröhling
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Summary:The molecular genetic landscape of leiomyosarcoma (LMS) is largely unknown. Here, the authors identify frequent DNA copy number alterations, whole-genome duplication, <i>TP53</i> and <i>RB1</i> inactivation, alternative telomere lengthening, and genomic imprints of defective DNA repair via homologous recombination as a potential therapeutic target in LMS patients.
Item Description:Gesehen am 11.01.2018
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-017-02602-0

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