Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation
Existing methods to improve motor function after stroke include non-specific neuromodulatory approaches. Here the authors use an automated method of analysis of reaching behaviour in rodents to show that optogenetic stimulation of intact corticospinal tract fibres leads to restoration of prior motor...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 October 2017
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| In: |
Nature Communications
Year: 2017, Jahrgang: 8 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-017-01090-6 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41467-017-01090-6 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-017-01090-6 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-017-01090-6.pdf 
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| Verfasserangaben: | A.S. Wahl, U. Büchler, A. Brändli, B. Brattoli, S. Musall, H. Kasper, B.V. Ineichen, F. Helmchen, B. Ommer, M.E. Schwab |
| Zusammenfassung: | Existing methods to improve motor function after stroke include non-specific neuromodulatory approaches. Here the authors use an automated method of analysis of reaching behaviour in rodents to show that optogenetic stimulation of intact corticospinal tract fibres leads to restoration of prior motor functions, rather than compensatory acquisition of new movements. |
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| Beschreibung: | Gesehen am 18.01.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-017-01090-6 |