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Optogenetically stimulating intact rat corticospinal tract post-stroke restores motor control through regionalized functional circuit formation

Existing methods to improve motor function after stroke include non-specific neuromodulatory approaches. Here the authors use an automated method of analysis of reaching behaviour in rodents to show that optogenetic stimulation of intact corticospinal tract fibres leads to restoration of prior motor...

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Bibliographic Details
Main Authors: Wahl, Anna-Sophia (Author) , Büchler, Uta (Author) , Brattoli, Biagio (Author) , Ommer, Björn (Author)
Format: Article (Journal)
Language:English
Published: 30 October 2017
In: Nature Communications
Year: 2017, Volume: 8
ISSN:2041-1723
DOI:10.1038/s41467-017-01090-6
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41467-017-01090-6
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-017-01090-6
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-017-01090-6.pdf
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Author Notes:A.S. Wahl, U. Büchler, A. Brändli, B. Brattoli, S. Musall, H. Kasper, B.V. Ineichen, F. Helmchen, B. Ommer, M.E. Schwab
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Summary:Existing methods to improve motor function after stroke include non-specific neuromodulatory approaches. Here the authors use an automated method of analysis of reaching behaviour in rodents to show that optogenetic stimulation of intact corticospinal tract fibres leads to restoration of prior motor functions, rather than compensatory acquisition of new movements.
Item Description:Gesehen am 18.01.2018
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-017-01090-6

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