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Novel prognostic markers derived from cardiovascular magnetic resonance imaging in patients with stable chronic coronary artery disease

Background: In patients with coronary artery disease (CAD), risk stratification remains a challenge. Recently, epicardial adipose tissue (EAT) assessed by cardiovascular magnetic resonance imaging (CMRI) has emerged as a new marker in patients with CAD. Thus, we aimed to investigate the association...

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Main Authors: Dösch, Christina (Author) , Streitner, Florian (Author) , Kuschyk, Jürgen (Author) , Akın, Ibrahim (Author) , Lehmann, Ralf (Author) , Loßnitzer, Dirk (Author) , Behnes, Michael (Author) , Schönberg, Stefan (Author) , Borggrefe, Martin (Author) , Papavassiliu, Theano (Author)
Format: Article (Journal)
Language:English
Published: November-December 2015
In: In vivo
Year: 2015, Volume: 29, Issue: 6, Pages: 737-747
ISSN:1791-7549
Online Access:Verlag, kostenfrei, Volltext: http://iv.iiarjournals.org/content/29/6/737
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Author Notes:Christina Doesch, Jan Jochims, Florian Streitner, Juergen Kuschyk, Ibrahim Akin, Ralf Lehmann, Dirk Lossnitzer, Michael Behnes, Stefan O. Schoenberg, Martin Borggrefe and Theano Papavassiliu
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Summary:Background: In patients with coronary artery disease (CAD), risk stratification remains a challenge. Recently, epicardial adipose tissue (EAT) assessed by cardiovascular magnetic resonance imaging (CMRI) has emerged as a new marker in patients with CAD. Thus, we aimed to investigate the association of CMR parameters with all-cause and cardiac mortality in patients with CAD. Patients and Methods: CMRI examination was performed in 260 patients with CAD. Results: In the 40 patients who died, left ventricular (LV) ejection fraction, right ventricular fractioning shortening, LV remodeling index and indexed EAT were significantly reduced, whereas LV mass index, LV end-diastolic volume index, LV end-systolic volume index, LV end-diastolic diameter and the extent of late gadolinium enhancement expressed as a percentage of the maximum possible score to estimate the extent of LGE relative to LV mass (LGE %), were significantly elevated. Using multivariate analysis, age, LV mass index, extent of LGE % and indexed EAT proved to be independently associated with all-cause and cardiac mortality. Conclusion: Age, LV mass index, the extent of LGE % and indexed EAT are independent predictors of mortality that might contribute to a more accurate risk stratification of patients with CAD.
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Gesehen am 24.01.2018
Physical Description:Online Resource
ISSN:1791-7549

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