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Anti-aging and antioxidant potential of Paullinia cupana var. sorbilis: findings in Caenorhabditis elegans indicate a new utilization for roasted seeds of guarana

Background: Roasted seeds of Amazonian guarana (Paullinia cupana var. sorbilis; Sapindaceae) are popular in South America due to their stimulant activity on the central nervous system (CNS). Rich in purine alkaloids, markedly caffeine, the seeds are extensively used in the Brazilian beverage industr...

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Main Authors: Peixoto, Herbenya (Author) , Roxo, Mariana (Author) , Röhrig, Teresa (Author) , Richling, Elke (Author) , Wang, Xiaojuan (Author) , Wink, Michael (Author)
Format: Article (Journal)
Language:English
Published: 15 August 2017
In: Medicines
Year: 2017, Volume: 4, Issue: 3
ISSN:2305-6320
DOI:10.3390/medicines4030061
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.3390/medicines4030061
Verlag, kostenfrei, Volltext: http://www.mdpi.com/2305-6320/4/3/61
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Author Notes:Herbenya Peixoto, Mariana Roxo, Teresa Röhrig, Elke Richling, Xiaojuan Wang, Michael Wink
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Summary:Background: Roasted seeds of Amazonian guarana (Paullinia cupana var. sorbilis; Sapindaceae) are popular in South America due to their stimulant activity on the central nervous system (CNS). Rich in purine alkaloids, markedly caffeine, the seeds are extensively used in the Brazilian beverage industry for the preparation of soft drinks and as additives in energy drinks. Methods: To investigate the putative anti-aging and antioxidant activity of guarana, we used the model organism Caenorhabditis elegans. Chemical analyses were performed using high-performance liquid chromatography (HPLC) and electrospray ionization-mass spectrometry (ESI-MS/MS). Results: When tested in the model system Caenorhabditis elegans, the water extract from roasted guarana seeds enhanced resistance against oxidative stress, extended lifespan and attenuated aging markers such as muscle function decline and polyQ40 aggregation. Conclusions: In the current study, we demonstrate that guarana extracts can work as a powerful antioxidant in vivo; moreover, guarana extracts exhibit anti-aging properties. Our results suggest that the biological activities of guarana go beyond the extensively reported CNS stimulation.
Item Description:Gesehen am 19.02.2018
Physical Description:Online Resource
ISSN:2305-6320
DOI:10.3390/medicines4030061

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