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Three-dimensional polymer coated 45S5-type bioactive glass scaffolds seeded with human mesenchymal stem cells show bone formation in vivo

45S5-type bioactive glasses are a promising alternative to established substitutes for the treatment of bone defects. Because the three-dimensional (3D) structure of bone substitutes is crucial for bone ingrowth and formation, we evaluated the osteoinductive properties of different polymer coated 3D...

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Main Authors: Westhauser, Fabian (Author) , Weis, Christian (Author) , Prokscha, Matthäus (Author) , Xiao, Kai (Author) , Kneser, Ulrich (Author) , Kauczor, Hans-Ulrich (Author) , Schmidmaier, Gerhard (Author) , Moghaddam-Alvandi, Arash (Author)
Format: Article (Journal)
Language:English
Published: 7 June 2016
In: Journal of materials science
Year: 2016, Volume: 27, Issue: 7, Pages: 119
ISSN:1573-4838
DOI:10.1007/s10856-016-5732-3
Online Access:Verlag, Volltext: http://dx.doi.org/10.1007/s10856-016-5732-3
Verlag, Volltext: https://link.springer.com/article/10.1007/s10856-016-5732-3
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Author Notes:Fabian Westhauser, Christian Weis, Matthäus Prokscha, Leonie A. Bittrich, Wei Li, Kai Xiao, Ulrich Kneser, Hans-Ulrich Kauczor, Gerhard Schmidmaier, Aldo R. Boccaccini, Arash Moghaddam
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Summary:45S5-type bioactive glasses are a promising alternative to established substitutes for the treatment of bone defects. Because the three-dimensional (3D) structure of bone substitutes is crucial for bone ingrowth and formation, we evaluated the osteoinductive properties of different polymer coated 3D-45S5 bioactive glass (BG) scaffolds seeded with human mesenchymal stem cells (hMSC) in vivo. BG scaffolds coated with gelatin, cross-linked gelatin, and poly(3-hydroxybutyrate-co-3-hydroxyvalerate) were seeded with hMSC prior to implantation into severe combined immunodeficiency mice. Newly formed bone was evaluated with histomorphometry and micro-computed tomography. Bone formation was detectable in all groups, whereas the gelatin-coated BG scaffolds showed the best results and should be considered in further studies.Graphical Abstract Open image in new window
Item Description:Gesehen am 19.02.2018
Physical Description:Online Resource
ISSN:1573-4838
DOI:10.1007/s10856-016-5732-3

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