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Does comorbid disruptive behavior modify the effects of atomoxetine on ADHD symptoms as measured by a continuous performance test and a motion tracking device?

Objective: To compare the reduction of ADHD symptoms under atomoxetine in patients with and without comorbid oppositional defiant disorder (ODD) or conduct disorder (CD) using a computer-based continuous performance test (cb-CPT) combined with an infrared motion tracking (MT) device. Method: Seconda...

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Bibliographic Details
Main Authors: Wehmeier, Peter M. (Author) , Banaschewski, Tobias (Author) , Dittmann, Ralf (Author)
Format: Article (Journal)
Language:English
Published: 2015
In: Journal of attention disorders
Year: 2015, Volume: 19, Issue: 7, Pages: 591-602
ISSN:1557-1246
DOI:10.1177/1087054712456739
Online Access:Verlag, Volltext: http://dx.doi.org/10.1177/1087054712456739
Verlag, Volltext: https://doi.org/10.1177/1087054712456739
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Author Notes:Peter M. Wehmeier, Laura Kipp, Tobias Banaschewski, Ralf W. Dittmann, and Alexander Schacht
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Summary:Objective: To compare the reduction of ADHD symptoms under atomoxetine in patients with and without comorbid oppositional defiant disorder (ODD) or conduct disorder (CD) using a computer-based continuous performance test (cb-CPT) combined with an infrared motion tracking (MT) device. Method: Secondary analysis of a placebo-controlled study in ADHD patients (6-12 years old) treated with atomoxetine (target dose: 1.2 mg/kg per day). Cb-CPT/MT scores were analyzed using ANCOVA (last observation carried forward [LOCF]). Results: The data (N = 125) suggested a more pronounced atomoxetine effect in the group with comorbid ODD/CD as measured by all cb-CPT/MT parameters except for “normalized variation of reaction time” (nVRT). Conclusion: The results showed that atomoxetine reduced ADHD severity as measured by cb-CPT and MT parameters regardless of whether comorbid ODD/CD was present. The treatment effect of atomoxetine on hyperactivity appears to be more pronounced in the subgroup of patients with comorbid ODD/CD than in the subgroup without this comorbidity.
Item Description:Gesehen am 15.03.2018
Physical Description:Online Resource
ISSN:1557-1246
DOI:10.1177/1087054712456739

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