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Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα during the LPS-mediated immune response of murine macrophages

Liver endothelial differentiation-associated protein-1 (Leda-1/Pianp) is a type-I-transmembrane protein that is able to bind and activate immune inhibitory receptor Pilrα. Here we show that Leda-1/Pianp is strain-specifically expressed in lymphoid organs and macrophages of Th2-prone BALB/c mice but...

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Main Authors: Biswas, Siladitta (Author) , Adrian, Monica (Author) , Schledzewski, Kai (Author) , Weber, Jochen (Author) , Winkler, Manuel (Author) , Goerdt, Sergij (Author) , Géraud, Cyrill (Author)
Format: Article (Journal)
Language:English
Published: 4 September 2015
In: Biochemical and biophysical research communications
Year: 2015, Volume: 464, Issue: 4, Pages: 1078-1083
ISSN:1090-2104
DOI:10.1016/j.bbrc.2015.07.079
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.bbrc.2015.07.079
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0006291X15303090
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Author Notes:Siladitta Biswas, Monica Adrian, Konstantin Evdokimov, Kai Schledzewski, Jochen Weber, Manuel Winkler, Sergij Goerdt, Cyrill Géraud
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Summary:Liver endothelial differentiation-associated protein-1 (Leda-1/Pianp) is a type-I-transmembrane protein that is able to bind and activate immune inhibitory receptor Pilrα. Here we show that Leda-1/Pianp is strain-specifically expressed in lymphoid organs and macrophages of Th2-prone BALB/c mice but not of Th1-prone C57BL/6J mice. LPS stimulation of BALB/c bone marrow-derived macrophages (BMM) and macrophage-like Raw 264.7 cells conversely regulated Leda-1/Pianp and Pilrα expression. Pilrα induction was caused by LPS-mediated transcriptional modulation and increased mRNA expression. On the other hand, the LPS-mediated decline of Leda-1/Pianp expression was the result of proteolytic degradation by matrix metalloproteinases. In summary, these findings demonstrate that counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilrα is part of the complex innate immune response of macrophages and its genetically determined strain-specific modulation.
Item Description:Gesehen am 22.03.2018
Physical Description:Online Resource
ISSN:1090-2104
DOI:10.1016/j.bbrc.2015.07.079

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