Cover Image

Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy

The receptor for Advanced Glycation End products (RAGE) is implicated in the pathogenesis of diabetic complications, but its importance in diabetic embryopathy is unclear. We therefore investigated the role of RAGE in diabetic embryopathy using streptozotocin induced diabetes in female wild type (WT...

Full description

Saved in:
Bibliographic Details
Main Authors: Ejdesjö, Andreas (Author) , Brings, Sebastian (Author) , Fleming, Thomas (Author) , Nawroth, Peter Paul (Author)
Format: Article (Journal)
Language:English
Published: 22 April 2016
In: Reproductive toxicology
Year: 2016, Volume: 62, Pages: 62-70
ISSN:1873-1708
DOI:10.1016/j.reprotox.2016.04.015
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.reprotox.2016.04.015
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S089062381630065X
Get full text
Author Notes:Andreas Ejdesjö, Sebastian Brings, Thomas Fleming, Rikard G. Fred, Peter P. Nawroth, Ulf J. Eriksson
Description
Summary:The receptor for Advanced Glycation End products (RAGE) is implicated in the pathogenesis of diabetic complications, but its importance in diabetic embryopathy is unclear. We therefore investigated the role of RAGE in diabetic embryopathy using streptozotocin induced diabetes in female wild type (WT) C57Bl/6N and RAGE knockout C57Bl/6N (RAGE−/−) mice, mated with control males of the same genotype. Maternal diabetes induced more fetal resorption and malformation (facial skeleton, neural tube) in the WT than in the RAGE−/− fetuses. Maternal plasma glucose and methylgyoxal concentrations, as well as embryonic N(ε)-carboxymethyl-lysine (CML) levels were increased to the same extent in diabetic WT and RAGE−/− pregnancy. However, maternal diabetes induced increased fetal hepatic isoprostane 8-iso-PGF2α levels (oxidative stress marker) and embryonic activation of NFκB in WT only (not in RAGE−/− embryos). The association between RAGE knockout and diminished embryonic dysmorphogenesis in diabetic pregnancy suggests that embryonic RAGE activation is involved in diabetic embryopathy.
Item Description:Gesehen am 23.03.2018
Physical Description:Online Resource
ISSN:1873-1708
DOI:10.1016/j.reprotox.2016.04.015

Similar Items